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Multicenter automatic defibrillator implantation trial: reduce inappropriate therapy (MADIT-RIT): background, rationale, and clinical protocol.

Publication ,  Journal Article
Schuger, C; Daubert, JP; Brown, MW; Cannom, D; Estes, NAM; Hall, WJ; Kayser, T; Klein, H; Olshansky, B; Power, KA; Wilber, D; Zareba, W; Moss, AJ
Published in: Ann Noninvasive Electrocardiol
July 2012

The implantable cardioverter defibrillator (ICD) is highly effective in reducing mortality due to cardiac arrhythmias in high-risk cardiac patients. However, inappropriate therapies caused predominantly by supraventricular tachyarrhythmias (SVTs) remain a significant side effect of ICD therapy despite medical treatment, affecting 8-40% of patients. The MADIT-RIT is a global, prospective, randomized, nonblinded, three-arm, multicenter clinical investigation to be performed in the Unites States, Europe, Canada, Israel and Japan, and will utilize approximately 90 centers with plan to enroll 1500 patients programmed to three treatment arms. The objective of the MADIT-RIT trial is to determine if dual-chamber ICD or CRT-D devices with high rate cutoff (MADIT-RIT-Arm B) and/or long delay in combination with detection enhancements (MADIT-RIT-Arm C) are associated with fewer patients experiencing inappropriate therapies than standard programming (MADIT-RIT-Arm A) during postimplant follow-up of patients with indication for primary prevention device therapy. This paper describes design and analytic plan for the MADIT-RIT trial.

Duke Scholars

Published In

Ann Noninvasive Electrocardiol

DOI

EISSN

1542-474X

Publication Date

July 2012

Volume

17

Issue

3

Start / End Page

176 / 185

Location

United States

Related Subject Headings

  • United States
  • Treatment Outcome
  • Tachycardia, Supraventricular
  • Survival Analysis
  • Risk Assessment
  • Reference Values
  • Prospective Studies
  • Proportional Hazards Models
  • Prognosis
  • Patient Selection
 

Citation

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Chicago
ICMJE
MLA
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Schuger, C., Daubert, J. P., Brown, M. W., Cannom, D., Estes, N. A. M., Hall, W. J., … Moss, A. J. (2012). Multicenter automatic defibrillator implantation trial: reduce inappropriate therapy (MADIT-RIT): background, rationale, and clinical protocol. Ann Noninvasive Electrocardiol, 17(3), 176–185. https://doi.org/10.1111/j.1542-474X.2012.00531.x
Schuger, Claudio, James P. Daubert, Mary W. Brown, David Cannom, NA Mark Estes, W Jackson Hall, Torsten Kayser, et al. “Multicenter automatic defibrillator implantation trial: reduce inappropriate therapy (MADIT-RIT): background, rationale, and clinical protocol.Ann Noninvasive Electrocardiol 17, no. 3 (July 2012): 176–85. https://doi.org/10.1111/j.1542-474X.2012.00531.x.
Schuger C, Daubert JP, Brown MW, Cannom D, Estes NAM, Hall WJ, et al. Multicenter automatic defibrillator implantation trial: reduce inappropriate therapy (MADIT-RIT): background, rationale, and clinical protocol. Ann Noninvasive Electrocardiol. 2012 Jul;17(3):176–85.
Schuger, Claudio, et al. “Multicenter automatic defibrillator implantation trial: reduce inappropriate therapy (MADIT-RIT): background, rationale, and clinical protocol.Ann Noninvasive Electrocardiol, vol. 17, no. 3, July 2012, pp. 176–85. Pubmed, doi:10.1111/j.1542-474X.2012.00531.x.
Schuger C, Daubert JP, Brown MW, Cannom D, Estes NAM, Hall WJ, Kayser T, Klein H, Olshansky B, Power KA, Wilber D, Zareba W, Moss AJ. Multicenter automatic defibrillator implantation trial: reduce inappropriate therapy (MADIT-RIT): background, rationale, and clinical protocol. Ann Noninvasive Electrocardiol. 2012 Jul;17(3):176–185.
Journal cover image

Published In

Ann Noninvasive Electrocardiol

DOI

EISSN

1542-474X

Publication Date

July 2012

Volume

17

Issue

3

Start / End Page

176 / 185

Location

United States

Related Subject Headings

  • United States
  • Treatment Outcome
  • Tachycardia, Supraventricular
  • Survival Analysis
  • Risk Assessment
  • Reference Values
  • Prospective Studies
  • Proportional Hazards Models
  • Prognosis
  • Patient Selection