The utility of troponin measurement to detect myocardial infarction: review of the current findings.

Published online

Journal Article (Review)

Myocardial infarction (MI) is defined by the presence of myocardial necrosis in combination with clinical evidence of myocardial ischemia. Cardiac troponins are regulatory proteins within the myocardium that are released into the circulation when damage to the myocyte has occurred. Therefore, serum troponin is an exquisitely sensitive marker of myocardial injury and is necessary for establishing the diagnosis of MI. High-sensitivity troponin assays are improving the diagnostic accuracy and rapid detection of myocardial infarction. The early identification of MI is vital for the institution of anti-thrombotic therapy to limit myocardial damage and preserve cardiac function. Troponin has both diagnostic and prognostic significance in the setting of acute coronary syndrome (ACS). Increased troponin levels in the absence of ACS should prompt an evaluation for an alternative, non-thrombotic mechanism of troponin elevation and direct management at the underlying cause. This review describes the role of troponin in the evaluation of patients with suspected myocardial infarction.

Full Text

Duke Authors

Cited Authors

  • Daubert, MA; Jeremias, A

Published Date

  • September 7, 2010

Published In

Volume / Issue

  • 6 /

Start / End Page

  • 691 - 699

PubMed ID

  • 20859540

Pubmed Central ID

  • 20859540

Electronic International Standard Serial Number (EISSN)

  • 1178-2048

Digital Object Identifier (DOI)

  • 10.2147/vhrm.s5306

Language

  • eng

Conference Location

  • New Zealand