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Identification of a proliferation signature related to survival in nodal peripheral T-cell lymphomas.

Publication ,  Journal Article
Cuadros, M; Dave, SS; Jaffe, ES; Honrado, E; Milne, R; Alves, J; Rodríguez, J; Zajac, M; Benitez, J; Staudt, LM; Martinez-Delgado, B
Published in: J Clin Oncol
August 1, 2007

PURPOSE: Nodal peripheral T-cell lymphomas (PTCLs) constitute a heterogeneous group of neoplasms, suggesting the existence of molecular differences contributing to their histologic and clinical variability. Initial expression profiling studies of T-cell lymphomas have been inconclusive in yielding clinically relevant insights. We applied DNA microarrays to gain insight into the molecular signatures associated with prognosis. MATERIALS AND METHODS: We analyzed the expression profiles of 35 nodal PTCLs (23 PTCLs unspecified and 12 angioimmunoblastic) using two different microarray platforms, the cDNA microarray developed at the Spanish National Cancer Centre and an oligonucleotide microarray. RESULTS: We identified five clusters of genes, the expression of which varied significantly among the samples. Genes in these clusters seemed to be functionally related to different cellular processes such as proliferation, inflammatory response, and T-cell or B-cell lineages. Regardless of the microarray platform used, overexpression of genes in the proliferation signature was associated significantly with shorter survival of patients. This proliferation signature included genes commonly associated with the cell cycle, such as CCNA, CCNB, TOP2A, and PCNA. Moreover the PTCL proliferation signature showed a statistically significant inverse correlation with clusters of the inflammatory response (P < .0001), as well as with the percentage of CD68(+) cells. CONCLUSION: Our findings indicate that proliferation could be an important factor in evaluating nodal PTCL outcome and may help to define a more aggressive phenotype.

Duke Scholars

Published In

J Clin Oncol

DOI

EISSN

1527-7755

Publication Date

August 1, 2007

Volume

25

Issue

22

Start / End Page

3321 / 3329

Location

United States

Related Subject Headings

  • Survival Analysis
  • Statistics, Nonparametric
  • Proportional Hazards Models
  • Predictive Value of Tests
  • Oncology & Carcinogenesis
  • Lymphoma, T-Cell
  • Lymph Nodes
  • Immunohistochemistry
  • Humans
  • Gene Expression Regulation, Neoplastic
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Cuadros, M., Dave, S. S., Jaffe, E. S., Honrado, E., Milne, R., Alves, J., … Martinez-Delgado, B. (2007). Identification of a proliferation signature related to survival in nodal peripheral T-cell lymphomas. J Clin Oncol, 25(22), 3321–3329. https://doi.org/10.1200/JCO.2006.09.4474
Cuadros, Marta, Sandeep S. Dave, Elaine S. Jaffe, Emiliano Honrado, Roger Milne, Javier Alves, Jose Rodríguez, et al. “Identification of a proliferation signature related to survival in nodal peripheral T-cell lymphomas.J Clin Oncol 25, no. 22 (August 1, 2007): 3321–29. https://doi.org/10.1200/JCO.2006.09.4474.
Cuadros M, Dave SS, Jaffe ES, Honrado E, Milne R, Alves J, et al. Identification of a proliferation signature related to survival in nodal peripheral T-cell lymphomas. J Clin Oncol. 2007 Aug 1;25(22):3321–9.
Cuadros, Marta, et al. “Identification of a proliferation signature related to survival in nodal peripheral T-cell lymphomas.J Clin Oncol, vol. 25, no. 22, Aug. 2007, pp. 3321–29. Pubmed, doi:10.1200/JCO.2006.09.4474.
Cuadros M, Dave SS, Jaffe ES, Honrado E, Milne R, Alves J, Rodríguez J, Zajac M, Benitez J, Staudt LM, Martinez-Delgado B. Identification of a proliferation signature related to survival in nodal peripheral T-cell lymphomas. J Clin Oncol. 2007 Aug 1;25(22):3321–3329.

Published In

J Clin Oncol

DOI

EISSN

1527-7755

Publication Date

August 1, 2007

Volume

25

Issue

22

Start / End Page

3321 / 3329

Location

United States

Related Subject Headings

  • Survival Analysis
  • Statistics, Nonparametric
  • Proportional Hazards Models
  • Predictive Value of Tests
  • Oncology & Carcinogenesis
  • Lymphoma, T-Cell
  • Lymph Nodes
  • Immunohistochemistry
  • Humans
  • Gene Expression Regulation, Neoplastic