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CT metrics of airway disease and emphysema in severe COPD.

Publication ,  Other
Kim, WJ; Silverman, EK; Hoffman, E; Criner, GJ; Mosenifar, Z; Sciurba, FC; Make, BJ; Carey, V; San José Estépar, R; Diaz, A; Reilly, JJ ...
Published in: Chest
August 2009

BACKGROUND: CT scan measures of emphysema and airway disease have been correlated with lung function in cohorts of subjects with a range of COPD severity. The contribution of CT scan-assessed airway disease to objective measures of lung function and respiratory symptoms such as dyspnea in severe emphysema is less clear. METHODS: Using data from 338 subjects in the National Emphysema Treatment Trial (NETT) Genetics Ancillary Study, densitometric measures of emphysema using a threshold of -950 Hounsfield units (%LAA-950) and airway wall phenotypes of the wall thickness (WT) and the square root of wall area (SRWA) of a 10-mm luminal perimeter airway were calculated for each subject. Linear regression analysis was performed for outcome variables FEV(1) and percent predicted value of FEV(1) with CT scan measures of emphysema and airway disease. RESULTS: In univariate analysis, there were significant negative correlations between %LAA-950 and both the WT (r = -0.28, p = 0.0001) and SRWA (r = -0.19, p = 0.0008). Airway wall thickness was weakly but significantly correlated with postbronchodilator FEV(1)% predicted (R = -0.12, p = 0.02). Multivariate analysis showed significant associations between either WT or SRWA (beta = -5.2, p = 0.009; beta = -2.6, p = 0.008, respectively) and %LAA-950 (beta = -10.6, p = 0.03) with the postbronchodilator FEV(1)% predicted. Male subjects exhibited significantly thicker airway wall phenotypes (p = 0.007 for WT and p = 0.0006 for SRWA). CONCLUSIONS: Airway disease and emphysema detected by CT scanning are inversely related in patients with severe COPD. Airway wall phenotypes were influenced by gender and associated with lung function in subjects with severe emphysema.

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Published In

Chest

DOI

EISSN

1931-3543

Publication Date

August 2009

Volume

136

Issue

2

Start / End Page

396 / 404

Location

United States

Related Subject Headings

  • Total Lung Capacity
  • Tomography, X-Ray Computed
  • Severity of Illness Index
  • Sensitivity and Specificity
  • Risk Assessment
  • Respiratory System
  • Respiratory Function Tests
  • Pulmonary Ventilation
  • Pulmonary Emphysema
  • Pulmonary Disease, Chronic Obstructive
 

Citation

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Kim, W. J., Silverman, E. K., Hoffman, E., Criner, G. J., Mosenifar, Z., Sciurba, F. C., … NETT Research Group, . (2009). CT metrics of airway disease and emphysema in severe COPD. Chest. United States. https://doi.org/10.1378/chest.08-2858
Kim, Woo Jin, Edwin K. Silverman, Eric Hoffman, Gerard J. Criner, Zab Mosenifar, Frank C. Sciurba, Barry J. Make, et al. “CT metrics of airway disease and emphysema in severe COPD.Chest, August 2009. https://doi.org/10.1378/chest.08-2858.
Kim WJ, Silverman EK, Hoffman E, Criner GJ, Mosenifar Z, Sciurba FC, et al. CT metrics of airway disease and emphysema in severe COPD. Vol. 136, Chest. 2009. p. 396–404.
Kim, Woo Jin, et al. “CT metrics of airway disease and emphysema in severe COPD.Chest, vol. 136, no. 2, Aug. 2009, pp. 396–404. Pubmed, doi:10.1378/chest.08-2858.
Kim WJ, Silverman EK, Hoffman E, Criner GJ, Mosenifar Z, Sciurba FC, Make BJ, Carey V, San José Estépar R, Diaz A, Reilly JJ, Martinez FJ, Washko GR, NETT Research Group. CT metrics of airway disease and emphysema in severe COPD. Chest. 2009. p. 396–404.

Published In

Chest

DOI

EISSN

1931-3543

Publication Date

August 2009

Volume

136

Issue

2

Start / End Page

396 / 404

Location

United States

Related Subject Headings

  • Total Lung Capacity
  • Tomography, X-Ray Computed
  • Severity of Illness Index
  • Sensitivity and Specificity
  • Risk Assessment
  • Respiratory System
  • Respiratory Function Tests
  • Pulmonary Ventilation
  • Pulmonary Emphysema
  • Pulmonary Disease, Chronic Obstructive