Abnormalities in MRI-measured signal intensity in the corpus callosum in schizophrenia.


Journal Article

The microstructural integrity of the corpus callosum (CC) in first-episode schizophrenia patients was assessed by measuring the signal intensity (SI) in T1-weighted MRI images. Analyses revealed that compared to both healthy controls and non-schizophrenic patients, schizophrenia patients showed reductions in SI in all the callosal subregions, the genu, body, isthmus and splenium in first-episode schizophrenia. These results indicate that schizophrenia is characterized by pathology of this principal interhemispheric commissure; the abnormalities may reflect distributed (rather than localized) interhemispheric disconnectivity that extends beyond the heteromodal association cortices.

Full Text

Duke Authors

Cited Authors

  • Diwadkar, VA; DeBellis, MD; Sweeney, JA; Pettegrew, JW; Keshavan, MS

Published Date

  • April 1, 2004

Published In

Volume / Issue

  • 67 / 2-3

Start / End Page

  • 277 - 282

PubMed ID

  • 14984888

Pubmed Central ID

  • 14984888

International Standard Serial Number (ISSN)

  • 0920-9964

Digital Object Identifier (DOI)

  • 10.1016/S0920-9964(03)00098-7


  • eng

Conference Location

  • Netherlands