A pilot longitudinal study of hippocampal volumes in pediatric maltreatment-related posttraumatic stress disorder.


Journal Article

BACKGROUND: Adult posttraumatic stress disorder (PTSD) is associated with decreased hippocampal volumes; however, decreased hippocampal volumes were not seen in pediatric maltreatment-related PTSD. We examined hippocampal volumes longitudinally to determine if a history of childhood traumatic stress alters hippocampal growth during puberty. METHODS: Magnetic resonance imaging was used to measure temporal lobes, amygdala, and hippocampal volumes in nine prepubertal maltreated subjects with pediatric maltreatment-related PTSD and nine sociodemographically matched healthy nonmaltreated yoked control subjects at baseline and after at least 2 years follow-up (during the later stages of pubertal development) using identical equipment and measurement methodology. RESULTS: Temporal lobe, amygdala and hippocampal volumes did not differ between groups at baseline, follow-up, or across time. CONCLUSIONS: Whereas these data are from a small sample, the results do not support hippocampal changes in pediatric maltreatment-related PTSD.

Full Text

Duke Authors

Cited Authors

  • De Bellis, MD; Hall, J; Boring, AM; Frustaci, K; Moritz, G

Published Date

  • August 15, 2001

Published In

Volume / Issue

  • 50 / 4

Start / End Page

  • 305 - 309

PubMed ID

  • 11522266

Pubmed Central ID

  • 11522266

International Standard Serial Number (ISSN)

  • 0006-3223

Digital Object Identifier (DOI)

  • 10.1016/s0006-3223(01)01105-2


  • eng

Conference Location

  • United States