Corticotropin releasing hormone increases apparent potency of adrenocorticotropic hormone stimulation of cortisol secretion.


Journal Article (Review)

HYPOTHESIS: Corticotropin releasing hormone (CRH) has a regulatory effect on cortisol secretion in addition to its classic effect of stimulating adrenocorticotropic hormone (ACTH) secretion. REVIEW: There is growing evidence of "long-loop" and paracrine adrenal stimulation by CRH. Data from a study of the ovine-corticotropin releasing hormone (oCRH) stimulation test in 13 sexually abused girls and 13 normal controls was used in Montecarlo simulations of the hypothalamic-pituitary-adrenal axis, to get estimates of adrenal sensitivity to ACTH and cortisol elimination kinetics before and after oCRH administration. In both controls and sexually abused girls, ACTH had an apparent greater effect on cortisol secretion after administration of oCRH compared to its effect during the baseline period. This lends support to the hypothesis and suggests that it should be tested experimentally.

Full Text

Duke Authors

Cited Authors

  • Gonzalez-Heydrich, J; Steingard, RJ; Putnam, FW; De Bellis, MD; Beardslee, W; Kohane, IS

Published Date

  • November 2001

Published In

Volume / Issue

  • 57 / 5

Start / End Page

  • 544 - 548

PubMed ID

  • 11735308

Pubmed Central ID

  • 11735308

International Standard Serial Number (ISSN)

  • 0306-9877

Digital Object Identifier (DOI)

  • 10.1054/mehy.2001.1384


  • eng

Conference Location

  • United States