Anterior cingulate N-acetylaspartate/creatine ratios during clonidine treatment in a maltreated child with posttraumatic stress disorder.


Journal Article

Posttraumatic stress disorder in maltreated children is associated with dysregulation of biological stress systems, adverse brain development, and neuronal loss in the anterior cingulate region of the medial prefrontal cortex. A maltreated boy with posttraumatic stress disorder was followed prospectively using single voxel proton magnetic resonance spectroscopy measures of anterior cingulate N-acetylaspartate/creatine ratios, a marker of neural integrity. N-acetylaspartate/creatine ratios increased, and sleep measures improved upon symptom remission.

Full Text

Duke Authors

Cited Authors

  • De Bellis, MD; Keshavan, MS; Harenski, KA

Published Date

  • 2001

Published In

Volume / Issue

  • 11 / 3

Start / End Page

  • 311 - 316

PubMed ID

  • 11642482

Pubmed Central ID

  • 11642482

International Standard Serial Number (ISSN)

  • 1044-5463

Digital Object Identifier (DOI)

  • 10.1089/10445460152595649


  • eng

Conference Location

  • United States