N-Acetylaspartate concentration in the anterior cingulate of maltreated children and adolescents with PTSD.


Journal Article

OBJECTIVE: Anterior cingulate dysfunction has been implicated in the pathophysiology of posttraumatic stress disorder (PTSD). The authors hypothesized that integrity of the anterior cingulate may be affected in childhood PTSD. METHOD: Single voxel proton magnetic resonance spectroscopy (proton MRS) was used to measure the relative concentration of N-acetylaspartate and creatine, a marker of neural integrity, in the anterior cingulate of 11 children and adolescents who met DSM-IV criteria for PTSD secondary to maltreatment and 11 healthy matched comparison subjects. RESULTS: The ratio of N-acetylaspartate to creatine was significantly lower in the maltreated subjects with PTSD than in the comparison subjects. CONCLUSIONS: The lower N-acetylaspartate/creatine ratio in subjects with PTSD suggests that anterior cingulate neuronal metabolism may be altered in childhood PTSD.

Full Text

Duke Authors

Cited Authors

  • De Bellis, MD; Keshavan, MS; Spencer, S; Hall, J

Published Date

  • July 2000

Published In

Volume / Issue

  • 157 / 7

Start / End Page

  • 1175 - 1177

PubMed ID

  • 10873933

Pubmed Central ID

  • 10873933

International Standard Serial Number (ISSN)

  • 0002-953X

Digital Object Identifier (DOI)

  • 10.1176/appi.ajp.157.7.1175


  • eng

Conference Location

  • United States