Association of fluoxetine treatment with reductions in CSF concentrations of corticotropin-releasing hormone and arginine vasopressin in patients with major depression.

Published

Journal Article

The authors measured CSF concentrations of corticotropin-releasing hormone (CRH) and arginine vasopressin in nine depressed patients before and after fluoxetine treatment. They found significant decreases in CSF CRH, CSF arginine vasopressin, and Hamilton depression ratings. Thus, the therapeutic effect of this serotonin-uptake inhibitor may be related to diminution of these arousal-promoting neuropeptides.

Full Text

Duke Authors

Cited Authors

  • De Bellis, MD; Gold, PW; Geracioti, TD; Listwak, SJ; Kling, MA

Published Date

  • April 1993

Published In

Volume / Issue

  • 150 / 4

Start / End Page

  • 656 - 657

PubMed ID

  • 8465888

Pubmed Central ID

  • 8465888

International Standard Serial Number (ISSN)

  • 0002-953X

Digital Object Identifier (DOI)

  • 10.1176/ajp.150.4.656

Language

  • eng

Conference Location

  • United States