Facilitation of cocaine kindling by glucocorticoids in rats.


Journal Article

We report that glucocorticoids significantly facilitated the development of cocaine-induced kindled seizures. These results suggest that glucocorticoids may have effects on the development of kindled seizures which are similar to those of the neuropeptide, corticotropin-releasing hormone (CRH), with which they show a close functional relationship. These results may be of interest in the light of data showing that glucocorticoids increase CRH expression in the central nucleus of the amygdala, which is an important site for the development of kindling.

Full Text

Duke Authors

Cited Authors

  • Kling, MA; Smith, MA; Glowa, JR; Pluznik, D; Demas, J; DeBellis, MD; Gold, PW; Schulkin, J

Published Date

  • November 26, 1993

Published In

Volume / Issue

  • 629 / 1

Start / End Page

  • 163 - 166

PubMed ID

  • 8287272

Pubmed Central ID

  • 8287272

International Standard Serial Number (ISSN)

  • 0006-8993

Digital Object Identifier (DOI)

  • 10.1016/0006-8993(93)90497-b


  • eng

Conference Location

  • Netherlands