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IL-10 levels in Dengue patients: some findings from the exceptional epidemiological conditions in Cuba.

Publication ,  Journal Article
Pérez, AB; García, G; Sierra, B; Alvarez, M; Vázquez, S; Cabrera, MV; Rodríguez, R; Rosario, D; Martínez, E; Denny, T; Guzmán, MG
Published in: J Med Virol
June 2004

The pathogenesis associated with Dengue haemorrhagic fever, has yet to be fully elucidated, with no definitive in vivo evidence. The exceptional epidemiological circumstances in Cuba allow the evaluation of different mediators in a well-defined situation. In the present study, we describe the determination of levels of IL-12, IL-10 and RANTES in the sera of Cuban patients hospitalised with Dengue fever or Dengue haemorrhagic fever. The results showed that levels of serum IL-10 were higher in patients than controls, and those patients with secondary infections had consistently higher levels. All the Dengue haemorrhagic fever patients had increased levels of IL-10. In contrast, levels of IL-12 did not differ between patients and controls. Finally, RANTES serum levels detected in patients were lower than those observed in the controls. The association of increased levels of IL-10 in Dengue patients with a sequential infection suggests a possible role of this cytokine in the pathogenesis of Dengue disease.

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Published In

J Med Virol

DOI

ISSN

0146-6615

Publication Date

June 2004

Volume

73

Issue

2

Start / End Page

230 / 234

Location

United States

Related Subject Headings

  • Virology
  • Severe Dengue
  • Middle Aged
  • Interleukin-12
  • Interleukin-10
  • Humans
  • Dengue
  • Cuba
  • Chemokine CCL5
  • Adult
 

Citation

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Pérez, A. B., García, G., Sierra, B., Alvarez, M., Vázquez, S., Cabrera, M. V., … Guzmán, M. G. (2004). IL-10 levels in Dengue patients: some findings from the exceptional epidemiological conditions in Cuba. J Med Virol, 73(2), 230–234. https://doi.org/10.1002/jmv.20080
Pérez, Ana B., Gissel García, Beatriz Sierra, Mayling Alvarez, Susana Vázquez, María V. Cabrera, Rosmary Rodríguez, et al. “IL-10 levels in Dengue patients: some findings from the exceptional epidemiological conditions in Cuba.J Med Virol 73, no. 2 (June 2004): 230–34. https://doi.org/10.1002/jmv.20080.
Pérez AB, García G, Sierra B, Alvarez M, Vázquez S, Cabrera MV, et al. IL-10 levels in Dengue patients: some findings from the exceptional epidemiological conditions in Cuba. J Med Virol. 2004 Jun;73(2):230–4.
Pérez, Ana B., et al. “IL-10 levels in Dengue patients: some findings from the exceptional epidemiological conditions in Cuba.J Med Virol, vol. 73, no. 2, June 2004, pp. 230–34. Pubmed, doi:10.1002/jmv.20080.
Pérez AB, García G, Sierra B, Alvarez M, Vázquez S, Cabrera MV, Rodríguez R, Rosario D, Martínez E, Denny T, Guzmán MG. IL-10 levels in Dengue patients: some findings from the exceptional epidemiological conditions in Cuba. J Med Virol. 2004 Jun;73(2):230–234.
Journal cover image

Published In

J Med Virol

DOI

ISSN

0146-6615

Publication Date

June 2004

Volume

73

Issue

2

Start / End Page

230 / 234

Location

United States

Related Subject Headings

  • Virology
  • Severe Dengue
  • Middle Aged
  • Interleukin-12
  • Interleukin-10
  • Humans
  • Dengue
  • Cuba
  • Chemokine CCL5
  • Adult