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Is depression associated with immune activation?

Publication ,  Journal Article
Natelson, BH; Denny, T; Zhou, XD; LaManca, JJ; Ottenweller, JE; Tiersky, L; DeLuca, J; Gause, WC
Published in: J Affect Disord
May 1999

BACKGROUND: Some research immunologists have suggested that major depression amd chronic fatigue syndrome (CFS) are characterized by immune activation. To test this hypothesis, we compared immunological function in patients with major depression and in patients with CFS who developed major depression after the onset of CFS to that of sedentary healthy controls. METHODS: Subjects completed the Centers for Epidemiological Study-Depression (CES-D) questionnaire and allowed venisection. We performed flow cytometric analysis on 13 groups of white blood cells and used a reverse transcriptase PCR method to assay m-RNA of eight cytokines. RESULTS: CES-D scores were high in both patient groups and did not differ significantly. We found no evidence for immune activation in either patient group. Instead the data suggested immunological downregulation in depression. LIMITATIONS: Not all the subjects in the two patient groups were off antidepressants. CONCLUSIONS: The data indicate that immune activation is not necessary in depression--either alone or with CFS.

Duke Scholars

Published In

J Affect Disord

DOI

ISSN

0165-0327

Publication Date

May 1999

Volume

53

Issue

2

Start / End Page

179 / 184

Location

Netherlands

Related Subject Headings

  • Tumor Necrosis Factor Receptor Superfamily, Member 7
  • Surveys and Questionnaires
  • Psychiatry
  • Male
  • Humans
  • Female
  • Fatigue Syndrome, Chronic
  • Depressive Disorder, Major
  • Cytokines
  • Antigens, CD
 

Citation

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Natelson, B. H., Denny, T., Zhou, X. D., LaManca, J. J., Ottenweller, J. E., Tiersky, L., … Gause, W. C. (1999). Is depression associated with immune activation? J Affect Disord, 53(2), 179–184. https://doi.org/10.1016/s0165-0327(98)00118-9
Natelson, B. H., T. Denny, X. D. Zhou, J. J. LaManca, J. E. Ottenweller, L. Tiersky, J. DeLuca, and W. C. Gause. “Is depression associated with immune activation?J Affect Disord 53, no. 2 (May 1999): 179–84. https://doi.org/10.1016/s0165-0327(98)00118-9.
Natelson BH, Denny T, Zhou XD, LaManca JJ, Ottenweller JE, Tiersky L, et al. Is depression associated with immune activation? J Affect Disord. 1999 May;53(2):179–84.
Natelson, B. H., et al. “Is depression associated with immune activation?J Affect Disord, vol. 53, no. 2, May 1999, pp. 179–84. Pubmed, doi:10.1016/s0165-0327(98)00118-9.
Natelson BH, Denny T, Zhou XD, LaManca JJ, Ottenweller JE, Tiersky L, DeLuca J, Gause WC. Is depression associated with immune activation? J Affect Disord. 1999 May;53(2):179–184.
Journal cover image

Published In

J Affect Disord

DOI

ISSN

0165-0327

Publication Date

May 1999

Volume

53

Issue

2

Start / End Page

179 / 184

Location

Netherlands

Related Subject Headings

  • Tumor Necrosis Factor Receptor Superfamily, Member 7
  • Surveys and Questionnaires
  • Psychiatry
  • Male
  • Humans
  • Female
  • Fatigue Syndrome, Chronic
  • Depressive Disorder, Major
  • Cytokines
  • Antigens, CD