Decreased suppressor-inducer T lymphocytes in multiple sclerosis and other neurological diseases.

Journal Article (Journal Article)

Decreased numbers of CD4+CD45R+ suppressor-inducer T cells have been reported in patients with a variety of autoimmune diseases including systemic lupus erythematosus, rheumatoid arthritis and multiple sclerosis but not in patients with other neurological diseases. We now report our findings using murine monoclonal antibodies and two-color flow cytometric analysis on CD4+CD45R+ T cells in 22 patients with chronic progressive multiple sclerosis, 23 patients with other neurological diseases and 42 normal, healthy controls. Suppressor-inducer T cells were significantly reduced (p less than 0.001) in both patients with multiple sclerosis and other neurological diseases as compared to controls. Both patient populations had elevated helper T cell subset ratios. Thus, our data suggests that decreases in suppressor-inducer T cells may represent a common immunological defect among autoimmune and presumably non-autoimmune neurological disorders.

Full Text

Duke Authors

Cited Authors

  • Rohowsky-Kochan, C; Eiman, D; Troiano, R; Bansil, S; Oleske, J; Denny, T; Cook, SD

Published Date

  • July 1, 1990

Published In

Volume / Issue

  • 28 / 2

Start / End Page

  • 161 - 166

PubMed ID

  • 2141847

International Standard Serial Number (ISSN)

  • 0165-5728

Digital Object Identifier (DOI)

  • 10.1016/0165-5728(90)90030-q


  • eng

Conference Location

  • Netherlands