The acute toxicity and sublethal effects of chlorothalonil in channel catfish (Ictalurus punctatus)

Journal Article (Journal Article)

The in vivo toxicity and sublethal biochemical effects of chlorothalonil (2,4,5,6-tetrachloroisophthalonitrile) were evaluated in the channel catfish (lctalurus punctatus). The static 96hr LC50 value for chlorothalonil was 52 μg/L, indicating that chlorothalonil is highly acutely toxic to channel catfish. Sublethal chlorothalonil exposure for 6 days resulted in acute necrosis of the intestinal epithelial lining in 57% of the treated catfish. However, no treatment-related pathological lesions were observed in liver, gills, posterior kidney, brain, spleen, or heart. Catfish exposed to 13 μg/L chlorothalonil for 72 hr had increased tissue glutathione (GSH) concentrations in liver, posterior kidney and gills, suggesting a protective role of tissue GSH towards chlorothalonil exposure. © 1992.

Full Text

Duke Authors

Cited Authors

  • Gallagher, EP; Cattley, RC; Di Giulio, RT

Published Date

  • January 1, 1992

Published In

Volume / Issue

  • 24 / 1

Start / End Page

  • 3 - 10

International Standard Serial Number (ISSN)

  • 0045-6535

Digital Object Identifier (DOI)

  • 10.1016/0045-6535(92)90561-5

Citation Source

  • Scopus