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Recent events in alcoholic liver disease V. effects of ethanol on liver regeneration.

Publication ,  Journal Article
Diehl, AM
Published in: Am J Physiol Gastrointest Liver Physiol
January 2005

Liver regeneration is necessary to recover from alcoholic liver injury. Herein, we review evidence that ethanol interferes with liver regeneration. Briefly, alcoholic fatty livers demonstrate increased rates of hepatocyte death. The latter provides a regenerative stimulus. However, unlike mature hepatocytes in healthy adult livers, most surviving mature hepatocytes in alcoholic fatty livers cannot replicate. Therefore, less mature cells (progenitors) must differentiate to replace dead hepatocytes. Little is known about the general mechanisms that modulate the differentiation of liver progenitors in adults. Delineation of these mechanisms and clarification of how ethanol influences them might suggest new therapies for alcoholic liver disease.

Duke Scholars

Published In

Am J Physiol Gastrointest Liver Physiol

DOI

ISSN

0193-1857

Publication Date

January 2005

Volume

288

Issue

1

Start / End Page

G1 / G6

Location

United States

Related Subject Headings

  • Reactive Oxygen Species
  • Liver Regeneration
  • Liver Diseases, Alcoholic
  • Liver
  • Humans
  • Gastroenterology & Hepatology
  • Ethanol
  • Central Nervous System Depressants
  • Alcohol Drinking
  • 3208 Medical physiology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Diehl, A. M. (2005). Recent events in alcoholic liver disease V. effects of ethanol on liver regeneration. Am J Physiol Gastrointest Liver Physiol, 288(1), G1–G6. https://doi.org/10.1152/ajpgi.00376.2004
Diehl, Anna Mae. “Recent events in alcoholic liver disease V. effects of ethanol on liver regeneration.Am J Physiol Gastrointest Liver Physiol 288, no. 1 (January 2005): G1–6. https://doi.org/10.1152/ajpgi.00376.2004.
Diehl AM. Recent events in alcoholic liver disease V. effects of ethanol on liver regeneration. Am J Physiol Gastrointest Liver Physiol. 2005 Jan;288(1):G1–6.
Diehl, Anna Mae. “Recent events in alcoholic liver disease V. effects of ethanol on liver regeneration.Am J Physiol Gastrointest Liver Physiol, vol. 288, no. 1, Jan. 2005, pp. G1–6. Pubmed, doi:10.1152/ajpgi.00376.2004.
Diehl AM. Recent events in alcoholic liver disease V. effects of ethanol on liver regeneration. Am J Physiol Gastrointest Liver Physiol. 2005 Jan;288(1):G1–G6.

Published In

Am J Physiol Gastrointest Liver Physiol

DOI

ISSN

0193-1857

Publication Date

January 2005

Volume

288

Issue

1

Start / End Page

G1 / G6

Location

United States

Related Subject Headings

  • Reactive Oxygen Species
  • Liver Regeneration
  • Liver Diseases, Alcoholic
  • Liver
  • Humans
  • Gastroenterology & Hepatology
  • Ethanol
  • Central Nervous System Depressants
  • Alcohol Drinking
  • 3208 Medical physiology