Acetylcholine promotes the proliferation and collagen gene expression of myofibroblastic hepatic stellate cells.

Published

Journal Article

The mechanisms that initiate and perpetuate the fibrogenic response, during liver injury, are unclear. Animal studies, however, strongly support a role for the autonomic nervous system (ANS) in wound healing. Therefore, the ANS may also mediate the development of cirrhosis. Hepatic stellate cells (HSC), the liver's major matrix-producing cells, are activated by injury to become proliferative, fibrogenic myofibroblasts. HSC respond to sympathetic neurotransmitters by changing phenotype, suggesting that HSC may be the cellular effectors of ANS signals that modulate hepatic fibrogenesis during recovery from liver damage. We show here that the parasympathetic neurotransmitter acetylcholine markedly stimulates the proliferation of myofibroblastic HSC and induces HSC collagen gene expression in these cells. By extending evidence that HSC are direct targets of the ANS, these results support the proposed neuroglial role of HSC in the liver and suggest that interrupting ANS signalling may be useful in constraining the fibrogenic response to liver injury.

Full Text

Duke Authors

Cited Authors

  • Oben, JA; Yang, S; Lin, H; Ono, M; Diehl, AM

Published Date

  • January 3, 2003

Published In

Volume / Issue

  • 300 / 1

Start / End Page

  • 172 - 177

PubMed ID

  • 12480538

Pubmed Central ID

  • 12480538

International Standard Serial Number (ISSN)

  • 0006-291X

Digital Object Identifier (DOI)

  • 10.1016/s0006-291x(02)02773-0

Language

  • eng

Conference Location

  • United States