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Hepatic steatosis and type 2 diabetes mellitus.

Publication ,  Journal Article
Clark, JM; Diehl, AM
Published in: Curr Diab Rep
June 2002

Type 2 diabetes is strongly associated with nonalcoholic fatty liver disease (NAFLD), a spectrum of liver damage that ranges from relatively benign hepatic steatosis to potentially fatal cirrhosis. The severities of insulin resistance and liver damage parallel each other, with the greatest prevalence of cirrhosis occurring in cirrhotics. However, it is unknown whether one of these conditions causes the other, or if both are consequences of another process. Experimental evidence suggests that both insulin resistance and NAFLD result from a chronic inflammatory state. The mechanisms driving this chronic inflammation are unknown but might include the egress of products from intestinal bacteria into the portal blood, liver, and systemic circulation to trigger a sustained inflammatory cytokine response in genetically susceptible individuals. More research is needed to evaluate this hypothesis and to determine the benefits of treatments that interrupt this pathogenic cascade.

Duke Scholars

Published In

Curr Diab Rep

DOI

ISSN

1534-4827

Publication Date

June 2002

Volume

2

Issue

3

Start / End Page

210 / 215

Location

United States

Related Subject Headings

  • Insulin Resistance
  • Humans
  • Fatty Liver
  • Endocrinology & Metabolism
  • Disease Models, Animal
  • Diabetes Mellitus, Type 2
  • Animals
  • 3210 Nutrition and dietetics
  • 3202 Clinical sciences
  • 1117 Public Health and Health Services
 

Citation

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Chicago
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Clark, J. M., & Diehl, A. M. (2002). Hepatic steatosis and type 2 diabetes mellitus. Curr Diab Rep, 2(3), 210–215. https://doi.org/10.1007/s11892-002-0085-3
Clark, Jeanne M., and Anna Mae Diehl. “Hepatic steatosis and type 2 diabetes mellitus.Curr Diab Rep 2, no. 3 (June 2002): 210–15. https://doi.org/10.1007/s11892-002-0085-3.
Clark JM, Diehl AM. Hepatic steatosis and type 2 diabetes mellitus. Curr Diab Rep. 2002 Jun;2(3):210–5.
Clark, Jeanne M., and Anna Mae Diehl. “Hepatic steatosis and type 2 diabetes mellitus.Curr Diab Rep, vol. 2, no. 3, June 2002, pp. 210–15. Pubmed, doi:10.1007/s11892-002-0085-3.
Clark JM, Diehl AM. Hepatic steatosis and type 2 diabetes mellitus. Curr Diab Rep. 2002 Jun;2(3):210–215.
Journal cover image

Published In

Curr Diab Rep

DOI

ISSN

1534-4827

Publication Date

June 2002

Volume

2

Issue

3

Start / End Page

210 / 215

Location

United States

Related Subject Headings

  • Insulin Resistance
  • Humans
  • Fatty Liver
  • Endocrinology & Metabolism
  • Disease Models, Animal
  • Diabetes Mellitus, Type 2
  • Animals
  • 3210 Nutrition and dietetics
  • 3202 Clinical sciences
  • 1117 Public Health and Health Services