Nonalcoholic Steatohepatitis.


Journal Article (Review)

Nonalcoholic steatohepatitis (NASH) has become a major cause of cirrhosis and liver-related deaths worldwide. NASH is strongly associated with obesity and the metabolic syndrome, conditions that cause lipid accumulation in hepatocytes (hepatic steatosis). It is not well understood why some, but not other, individuals with hepatic steatosis develop NASH. The factors that determine whether or not NASH progresses to cirrhosis are also unclear. This review summarizes key components of NASH pathogenesis and discusses how inherent and acquired variations in regulation of these processes impact the risk for NASH and NASH cirrhosis.

Full Text

Duke Authors

Cited Authors

  • Suzuki, A; Diehl, AM

Published Date

  • January 14, 2017

Published In

Volume / Issue

  • 68 /

Start / End Page

  • 85 - 98

PubMed ID

  • 27732787

Pubmed Central ID

  • 27732787

Electronic International Standard Serial Number (EISSN)

  • 1545-326X

Digital Object Identifier (DOI)

  • 10.1146/annurev-med-051215-031109


  • eng

Conference Location

  • United States