Amyloid deposition detected with florbetapir F 18 ((18)F-AV-45) is related to lower episodic memory performance in clinically normal older individuals.

Journal Article

The objective of this study was to evaluate the relationship of amyloid burden, as assessed by florbetapir F 18 ((18)F-AV-45) amyloid positron emission tomography, and cognition in healthy older control (HC) subjects. Seventy-eight HC subjects were assessed with a brief cognitive test battery and positron emission tomography (PET) imaging with (18)F-AV-45. A standard uptake value ratio was computed for mean data from 6 cortical regions using a whole cerebellum reference region. Scans were also visually rated as amyloid positive or amyloid negative by 3 readers. Higher standard uptake value ratio correlated with lower immediate memory (r = -0.33; p = 0.003) and delayed recall scores (r = -0.25; p = 0.027). Performance on immediate recall was also lower in the visually rated amyloid positive compared with amyloid negative HC (p = 0.04), with a similar trend observed in delayed recall (p = 0.06). These findings support the hypothesis that higher amyloid burden is associated with lower memory performance among clinically normal older subjects. Longitudinal follow-up is ongoing to determine whether (18)F-AV-45 may also predict subsequent cognitive decline.

Full Text

Duke Authors

Cited Authors

  • Sperling, RA; Johnson, KA; Doraiswamy, PM; Reiman, EM; Fleisher, AS; Sabbagh, MN; Sadowsky, CH; Carpenter, A; Davis, MD; Lu, M; Flitter, M; Joshi, AD; Clark, CM; Grundman, M; Mintun, MA; Skovronsky, DM; Pontecorvo, MJ; AV45-A05 Study Group,

Published Date

  • March 2013

Published In

Volume / Issue

  • 34 / 3

Start / End Page

  • 822 - 831

PubMed ID

  • 22878163

Electronic International Standard Serial Number (EISSN)

  • 1558-1497

Digital Object Identifier (DOI)

  • 10.1016/j.neurobiolaging.2012.06.014

Language

  • eng

Conference Location

  • United States