Atypical antipsychotics and pituitary neoplasms in the WHO database.
Journal Article
Amisulpride and risperidone are potent dopamine D2 receptor blocking atypical antipsychotics that can cause hyperprolactinemia. Preclinical evidence shows that chronic administration of antipsychotics can cause pituitary adenomas in female mice. To investigate the clinical relevance in this finding, reports of pituitary neoplasms in the WHO adverse drug reaction (ADR) database were reviewed. Amisulpride and risperidone [corrected] had among the highest Information Component (IC) scores for benign pituitary neoplasm; amisulpride (IC = 3.31, IC025 = 1.83, 5 reports) and risperidone (IC = 4.03, IC025 = 3.33, 19 reports), and not otherwise specified (NOS) pituitary neoplasm: amisulpride (IC = 2.69, IC025 = 0.70, 3 reports) and risperidone (IC = 4.49, IC025 = 3.86, 23 reports). We conclude that there is a need for prospective studies to confirm causality and suggest that clinicians, until then, would consider a pituitary adenoma in patients experiencing severe hyperprolactinemia or associated symptoms when receiving potent D2 antagonists [corrected]
Full Text
Duke Authors
Cited Authors
- Doraiswamy, PM; Schott, G; Star, K; Edwards, R; Mueller-Oerlinghausen, B
Published Date
- 2007
Published In
Volume / Issue
- 40 / 1
Start / End Page
- 74 - 76
PubMed ID
- 17285098
Pubmed Central ID
- 17285098
International Standard Serial Number (ISSN)
- 0048-5764
Language
- eng
Conference Location
- United States