Baseline plasma GABA: its relationship to the adverse effects of acute lorazepam administration on cognition in the elderly.

Journal Article (Clinical Trial;Journal Article)

The GABA system is an active target for drugs to treat a variety of disorders and the availability of an indirect measure of central GABA activity would not only enhance psychiatric research, but also permit assessment of the pharmacodynamic effects of drugs designed to act on this system. The relationships between plasma baseline pre-drug GABA concentrations and cognitive impairments induced by an acute oral dose of lorazepam (0.5 and 1.0 mg) were investigated in 22 healthy elderly individuals. Partial correlations controlling for plasma lorazepam concentrations revealed no significant relationship between baseline plasma GABA levels and lorazepam-induced impairments on tests of cognitive functioning. Plasma GABA concentration does not appear to be a useful marker of susceptibility to benzodiazepine-induced cognitive toxicity in the elderly. Other approaches to estimating central GABA activity should be pursued.

Full Text

Duke Authors

Cited Authors

  • Pomara, N; Willoughby, LM; Sidtis, JJ; Doraiswamy, PM; Wesnes, KA; Cooper, TB; Greenblatt, DJ

Published Date

  • December 2004

Published In

Volume / Issue

  • 29 / 12

Start / End Page

  • 2311 - 2315

PubMed ID

  • 15672555

International Standard Serial Number (ISSN)

  • 0364-3190

Digital Object Identifier (DOI)

  • 10.1007/s11064-004-7041-3


  • eng

Conference Location

  • United States