The role of the N-methyl-D-aspartate receptor in Alzheimer's disease: therapeutic potential.

Journal Article (Journal Article;Review)

Alzheimer's disease (AD) is a progressive neurodegenerative disorder with an unknown etiology. Pathologic processes implicated in AD include b-amyloid-induced synaptic failure; tau hyperphosphorylation; inflammation; oxidative stress; abnormal neurotransmission involving acetylcholine, glutamate, norepinephrine, serotonin, and dopamine; and abnormalities in second messengers, protein kinases, and apoptosis. Although each of these pathways offers potential therapeutic targets, pharmacologic manipulation of the glutamatergic N-methyl-D-aspartate receptor pathway, alone or in combination with cholinergic therapies, is emerging as the next promising strategy for the treatment of AD and vascular dementia.

Full Text

Duke Authors

Cited Authors

  • Doraiswamy, PM

Published Date

  • September 2003

Published In

Volume / Issue

  • 3 / 5

Start / End Page

  • 373 - 378

PubMed ID

  • 12914679

International Standard Serial Number (ISSN)

  • 1528-4042

Digital Object Identifier (DOI)

  • 10.1007/s11910-003-0019-8


  • eng

Conference Location

  • United States