Current status of metals as therapeutic targets in Alzheimer's disease.

Published

Journal Article (Review)

There is accumulating evidence that interactions between beta-amyloid and copper, iron, and zinc are associated with the pathophysiology of Alzheimer's disease (AD). A significant dyshomeostasis of copper, iron, and zinc has been detected, and the mismanagement of these metals induces beta-amyloid precipitation and neurotoxicity. Chelating agents offer a potential therapeutic solution to the neurotoxicity induced by copper and iron dyshomeostasis. Currently, the copper and zinc chelating agent clioquinol represents a potential therapeutic route that may not only inhibit beta-amyloid neurotoxicity, but may also reverse the accumulation of neocortical beta-amyloid. A Phase II double-blind clinical trial of clioquinol with B12 supplementation will be published soon, and the results are promising. This article summarizes the role of transition metals in amyloidgenesis and reviews the potential promise of chelation therapy as a treatment for AD.

Full Text

Duke Authors

Cited Authors

  • Finefrock, AE; Bush, AI; Doraiswamy, PM

Published Date

  • August 2003

Published In

Volume / Issue

  • 51 / 8

Start / End Page

  • 1143 - 1148

PubMed ID

  • 12890080

Pubmed Central ID

  • 12890080

International Standard Serial Number (ISSN)

  • 0002-8614

Language

  • eng

Conference Location

  • United States