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Cardiac imaging approaches to evaluate drug-induced myocardial dysfunction.

Publication ,  Journal Article
Christian, JB; Finkle, JK; Ky, B; Douglas, PS; Gutstein, DE; Hockings, PD; Lainee, P; Lenihan, DJ; Mason, JW; Sager, PT; Todaro, TG; Hicks, KA ...
Published in: Am Heart J
December 2012

The ability to make informed benefit-risk assessments for potentially cardiotoxic new compounds is of considerable interest and importance at the public health, drug development, and individual patient levels. Cardiac imaging approaches in the evaluation of drug-induced myocardial dysfunction will likely play an increasing role. However, the optimal choice of myocardial imaging modality and the recommended frequency of monitoring are undefined. These decisions are complicated by the array of imaging techniques, which have varying sensitivities, specificities, availabilities, local expertise, safety, and costs, and by the variable time-course of tissue damage, functional myocardial depression, or recovery of function. This White Paper summarizes scientific discussions of members of the Cardiac Safety Research Consortium on the main factors to consider when selecting nonclinical and clinical cardiac function imaging techniques in drug development. We focus on 3 commonly used imaging modalities in the evaluation of cardiac function: echocardiography, magnetic resonance imaging, and radionuclide (nuclear) imaging and highlight areas for future research.

Duke Scholars

Published In

Am Heart J

DOI

EISSN

1097-6744

Publication Date

December 2012

Volume

164

Issue

6

Start / End Page

846 / 855

Location

United States

Related Subject Headings

  • Risk Assessment
  • Radionuclide Angiography
  • Magnetic Resonance Imaging
  • Humans
  • Echocardiography
  • Cardiovascular System & Hematology
  • Cardiovascular Agents
  • Cardiomyopathies
  • Cardiac Imaging Techniques
  • 3201 Cardiovascular medicine and haematology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Christian, J. B., Finkle, J. K., Ky, B., Douglas, P. S., Gutstein, D. E., Hockings, P. D., … Turner, J. R. (2012). Cardiac imaging approaches to evaluate drug-induced myocardial dysfunction. Am Heart J, 164(6), 846–855. https://doi.org/10.1016/j.ahj.2012.09.001
Christian, Jennifer B., John K. Finkle, Bonnie Ky, Pamela S. Douglas, David E. Gutstein, Paul D. Hockings, Pierre Lainee, et al. “Cardiac imaging approaches to evaluate drug-induced myocardial dysfunction.Am Heart J 164, no. 6 (December 2012): 846–55. https://doi.org/10.1016/j.ahj.2012.09.001.
Christian JB, Finkle JK, Ky B, Douglas PS, Gutstein DE, Hockings PD, et al. Cardiac imaging approaches to evaluate drug-induced myocardial dysfunction. Am Heart J. 2012 Dec;164(6):846–55.
Christian, Jennifer B., et al. “Cardiac imaging approaches to evaluate drug-induced myocardial dysfunction.Am Heart J, vol. 164, no. 6, Dec. 2012, pp. 846–55. Pubmed, doi:10.1016/j.ahj.2012.09.001.
Christian JB, Finkle JK, Ky B, Douglas PS, Gutstein DE, Hockings PD, Lainee P, Lenihan DJ, Mason JW, Sager PT, Todaro TG, Hicks KA, Kane RC, Ko H-S, Lindenfeld J, Michelson EL, Milligan J, Munley JY, Raichlen JS, Shahlaee A, Strnadova C, Ye B, Turner JR. Cardiac imaging approaches to evaluate drug-induced myocardial dysfunction. Am Heart J. 2012 Dec;164(6):846–855.
Journal cover image

Published In

Am Heart J

DOI

EISSN

1097-6744

Publication Date

December 2012

Volume

164

Issue

6

Start / End Page

846 / 855

Location

United States

Related Subject Headings

  • Risk Assessment
  • Radionuclide Angiography
  • Magnetic Resonance Imaging
  • Humans
  • Echocardiography
  • Cardiovascular System & Hematology
  • Cardiovascular Agents
  • Cardiomyopathies
  • Cardiac Imaging Techniques
  • 3201 Cardiovascular medicine and haematology