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Abnormal cardiac function in the streptozotocin-induced non-insulin-dependent diabetic rat: noninvasive assessment with doppler echocardiography and contribution of the nitric oxide pathway.

Publication ,  Journal Article
Joffe, II; Travers, KE; Perreault-Micale, CL; Hampton, T; Katz, SE; Morgan, JP; Douglas, PS
Published in: J Am Coll Cardiol
December 1999

OBJECTIVES: We sought to evaluate in vivo and in vitro left ventricular (LV) geometry and function in streptozotocin-induced diabetic rats and the possible role of the nitric oxide (NO) pathway. BACKGROUND: Diabetes results in cardiac dysfunction; however, the specific abnormalities are unknown. Because decreased NO contributes to abnormal vascular function in diabetics, we hypothesized that NO pathway abnormalities may contribute to diabetic cardiomyopathy. METHODS: Control rats and those with non-insulin-dependent diabetes mellitus (NIDDM) underwent echocardiography, hemodynamic assessment, isolated heart perfusion and measurement of exhaled NO and LV endothelial constitutive nitric oxide synthase (ecNOS). RESULTS: Diabetic rats had increased LV mass (3.3 +/- 0.6 vs. 2.6 +/- 0.3 g/g body weight [BW], p < 0.001) and cavity dimensions (diastolic 2.0 +/- 0.1 vs. 1.8 +/- 0.2 cm/cm tibial length [TL], p < 0.05). Diabetic rats had prolonged isovolumic relaxation time (IVRT) (40 +/- 8 vs. 26 +/- 6 ms, p < 0.0001), increased atrial contribution to diastolic filling (0.47 +/- 0.09 vs. 0.30 +/- 0.08 m/s, p < 0.0001), and elevated in vivo LV end-diastolic pressure (7 +/- 6 vs. 2 +/- 1 mm Hg, p = 0.04). Diabetic rats had increased chamber stiffness. Shortening was similar in both groups, despite reduced meridional wall stress in diabetics, suggesting impaired systolic contractility. Exhaled NO was lower in diabetic rats (1.8 +/- 0.2 vs. 3.3 +/- 0.3 parts per billion, p < 0.01) and correlated with Doppler LV filling. The ecNOS was similar between the groups. CONCLUSIONS: Diabetic cardiomyopathy is characterized by LV systolic and diastolic dysfunction, the latter correlating with decreased exhaled NO. The NO pathway is intact, suggesting impaired availability of NO as contributor to cardiomyopathy.

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Published In

J Am Coll Cardiol

DOI

ISSN

0735-1097

Publication Date

December 1999

Volume

34

Issue

7

Start / End Page

2111 / 2119

Location

United States

Related Subject Headings

  • Ventricular Function, Left
  • Rats, Sprague-Dawley
  • Rats
  • Nitric Oxide Synthase Type III
  • Nitric Oxide Synthase
  • Nitric Oxide
  • Myocardial Contraction
  • Heart Ventricles
  • Female
  • Echocardiography, Doppler
 

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Joffe, I. I., Travers, K. E., Perreault-Micale, C. L., Hampton, T., Katz, S. E., Morgan, J. P., & Douglas, P. S. (1999). Abnormal cardiac function in the streptozotocin-induced non-insulin-dependent diabetic rat: noninvasive assessment with doppler echocardiography and contribution of the nitric oxide pathway. J Am Coll Cardiol, 34(7), 2111–2119. https://doi.org/10.1016/s0735-1097(99)00436-2
Joffe, I. I., K. E. Travers, C. L. Perreault-Micale, T. Hampton, S. E. Katz, J. P. Morgan, and P. S. Douglas. “Abnormal cardiac function in the streptozotocin-induced non-insulin-dependent diabetic rat: noninvasive assessment with doppler echocardiography and contribution of the nitric oxide pathway.J Am Coll Cardiol 34, no. 7 (December 1999): 2111–19. https://doi.org/10.1016/s0735-1097(99)00436-2.
Joffe, I. I., et al. “Abnormal cardiac function in the streptozotocin-induced non-insulin-dependent diabetic rat: noninvasive assessment with doppler echocardiography and contribution of the nitric oxide pathway.J Am Coll Cardiol, vol. 34, no. 7, Dec. 1999, pp. 2111–19. Pubmed, doi:10.1016/s0735-1097(99)00436-2.
Joffe II, Travers KE, Perreault-Micale CL, Hampton T, Katz SE, Morgan JP, Douglas PS. Abnormal cardiac function in the streptozotocin-induced non-insulin-dependent diabetic rat: noninvasive assessment with doppler echocardiography and contribution of the nitric oxide pathway. J Am Coll Cardiol. 1999 Dec;34(7):2111–2119.
Journal cover image

Published In

J Am Coll Cardiol

DOI

ISSN

0735-1097

Publication Date

December 1999

Volume

34

Issue

7

Start / End Page

2111 / 2119

Location

United States

Related Subject Headings

  • Ventricular Function, Left
  • Rats, Sprague-Dawley
  • Rats
  • Nitric Oxide Synthase Type III
  • Nitric Oxide Synthase
  • Nitric Oxide
  • Myocardial Contraction
  • Heart Ventricles
  • Female
  • Echocardiography, Doppler