Gender differences in postinfarction left ventricular remodeling.

Journal Article

Objective

Previous studies suggest that gender affects the adaptive responses of the heart to some forms of cardiac overload. It is unknown whether gender influences left ventricular (LV) remodeling after myocardial infarction (MI).

Methods

We performed transthoracic echocardiographic-Doppler examinations in age-matched male (n = 17) and female (n = 16) rats before, and 1 and 6 weeks after transmural MI or sham surgery.

Results

Following large MI (male = 45 +/- 1% LV circumference vs. female = 48 +/- 4%, p = NS), both male and female rats developed progressive LV dilatation. Infarctions caused a similar degree of global and regional LV systolic dysfunction in males and females. Male rats had significant increases in the thickness of the noninfarcted posterior wall by 6 weeks after MI. However, posterior wall thickness did not change in the infarcted female rats. Average myocyte diameter in the noninfarcted region of the heart was also greater in male than female MI rats. The combination of increased cavity size with little change in wall thickness resulted in a greater decline in relative wall thickness in the female rats compared to the males. Male rats with MI showed progressively restricted LV diastolic filling as assessed by transmitral Doppler recordings. Female rats had less of an increase in the ratio of early to late transmitral velocities and less of an increase in the E wave deceleration rate after MI.

Conclusions

Female rats showed a different pattern of LV remodeling than males with less of an increase in thickness of the noninfarcted portions of the left ventricle than males, but comparable LV cavity enlargement and systolic dysfunction. Despite similar infarct size, females developed less pronounced abnormalities of LV diastolic filling. We hypothesize that the gender-related differences in postinfarction LV remodeling may contribute to the different LV filling patterns, and might ultimately relate to differences in clinical outcome.

Full Text

Duke Authors

Cited Authors

  • Litwin, SE; Katz, SE; Litwin, CM; Morgan, JP; Douglas, PS

Published Date

  • January 1999

Published In

Volume / Issue

  • 91 / 3

Start / End Page

  • 173 - 183

PubMed ID

  • 10516411

Pubmed Central ID

  • 10516411

Electronic International Standard Serial Number (EISSN)

  • 1421-9751

International Standard Serial Number (ISSN)

  • 0008-6312

Digital Object Identifier (DOI)

  • 10.1159/000006906

Language

  • eng