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Consequences of growth hormone deficiency on cardiac structure, function, and beta-adrenergic pathway: studies in mutant dwarf rats.

Publication ,  Journal Article
Cittadini, A; Strömer, H; Vatner, DE; Grossman, JD; Katz, SE; Clark, R; Morgan, JP; Douglas, PS
Published in: Endocrinology
December 1997

To evaluate GH's role in cardiac physiology and its interrelationship with the beta-adrenergic system, we studied GH-deficient dwarf (dw/dw) and control rats in 4 groups of 20 each: dwarf group receiving placebo, dwarf-GH group receiving 2 mg/kg GH, dwarf-GH-propranolol group receiving 2 mg/kg GH and 750 mg/liter propranolol, and a control group of Lewis rats receiving placebo. Dwarf rats showed reduced left ventricular weight and myocyte cross-sectional area, and impaired cardiac performance in vitro. Left ventricular pressure-volume curves showed a shift upward and leftward, indicating reduced distensibility. These abnormalities reversed after GH treatment regardless of concomitant propranolol administration. Although isoproterenol responsiveness was reduced in dwarf rats, there were no differences in beta-adrenergic receptor density, affinity, Na+,K+-adenosine triphosphatase activity, or adenylyl cyclase activity. In summary, myocyte size, cardiac structure, myocardial contractility, and distensibility are abnormal in GH deficiency. The effects of GH are not mediated by the beta-adrenergic pathway, which, in turn, is unaffected by changes in the GH-insulin-like growth factor I axis. Thus, GH plays a regulatory role in normal cardiac physiology that is independent of the beta-adrenergic system.

Duke Scholars

Published In

Endocrinology

DOI

ISSN

0013-7227

Publication Date

December 1997

Volume

138

Issue

12

Start / End Page

5161 / 5169

Location

United States

Related Subject Headings

  • Ventricular Function, Left
  • Receptors, Adrenergic, beta
  • Rats, Mutant Strains
  • Rats, Inbred Lew
  • Rats
  • Propranolol
  • Myocardium
  • Isoproterenol
  • In Vitro Techniques
  • Heart
 

Citation

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Cittadini, A., Strömer, H., Vatner, D. E., Grossman, J. D., Katz, S. E., Clark, R., … Douglas, P. S. (1997). Consequences of growth hormone deficiency on cardiac structure, function, and beta-adrenergic pathway: studies in mutant dwarf rats. Endocrinology, 138(12), 5161–5169. https://doi.org/10.1210/endo.138.12.5591
Cittadini, A., H. Strömer, D. E. Vatner, J. D. Grossman, S. E. Katz, R. Clark, J. P. Morgan, and P. S. Douglas. “Consequences of growth hormone deficiency on cardiac structure, function, and beta-adrenergic pathway: studies in mutant dwarf rats.Endocrinology 138, no. 12 (December 1997): 5161–69. https://doi.org/10.1210/endo.138.12.5591.
Cittadini A, Strömer H, Vatner DE, Grossman JD, Katz SE, Clark R, et al. Consequences of growth hormone deficiency on cardiac structure, function, and beta-adrenergic pathway: studies in mutant dwarf rats. Endocrinology. 1997 Dec;138(12):5161–9.
Cittadini, A., et al. “Consequences of growth hormone deficiency on cardiac structure, function, and beta-adrenergic pathway: studies in mutant dwarf rats.Endocrinology, vol. 138, no. 12, Dec. 1997, pp. 5161–69. Pubmed, doi:10.1210/endo.138.12.5591.
Cittadini A, Strömer H, Vatner DE, Grossman JD, Katz SE, Clark R, Morgan JP, Douglas PS. Consequences of growth hormone deficiency on cardiac structure, function, and beta-adrenergic pathway: studies in mutant dwarf rats. Endocrinology. 1997 Dec;138(12):5161–5169.
Journal cover image

Published In

Endocrinology

DOI

ISSN

0013-7227

Publication Date

December 1997

Volume

138

Issue

12

Start / End Page

5161 / 5169

Location

United States

Related Subject Headings

  • Ventricular Function, Left
  • Receptors, Adrenergic, beta
  • Rats, Mutant Strains
  • Rats, Inbred Lew
  • Rats
  • Propranolol
  • Myocardium
  • Isoproterenol
  • In Vitro Techniques
  • Heart