Optimal determination of right ventricular filling dynamics in systemic hypertension.

Journal Article (Journal Article)

To determine the optimal method of normalizing peak filling rate (PFR) determinations and apply it to the assessment of right ventricular (RV) and left ventricular (LV) filling characteristics and their interactions, 41 subjects with hypertension and 40 matched normals underwent echo-Doppler and nuclear study. Conventional normalization of PFR to end-diastolic volume (EDV) yielded poor correlations between nuclear- and echo-derived PFR (RV, r = 0.34; LV, r = 0.42), whereas nuclear and echo PFR normalized to stroke volume (SV) were closely correlated (RV, r = 0.87; LV, r = 0.92). Further, use of PFR normalized to SV revealed to close relation between RV and LV filling characteristics. Multivariate analysis confirmed that, in contrast to normalization to EDV or early to late filling-velocity ratios (E/A), peak filling rate normalized to SV was independent of ejection fraction and heart rate. In addition, RV filling impairment was related to LV filling impairment, and the effects of hypertension eliminated the independent influence of age on both LV and RV filling. In conclusion, normalization of PFR to SV may be preferable to use of EDV or E/A in evaluating RV and LV filling dynamics.

Full Text

Duke Authors

Cited Authors

  • Cittadini, A; Fazio, S; Strömer, H; Cuocolo, A; Sabatini, D; Imbriaco, M; Saccá, L; Douglas, PS

Published Date

  • November 1995

Published In

Volume / Issue

  • 130 / 5

Start / End Page

  • 1074 - 1082

PubMed ID

  • 7484739

International Standard Serial Number (ISSN)

  • 0002-8703

Digital Object Identifier (DOI)

  • 10.1016/0002-8703(95)90211-2


  • eng

Conference Location

  • United States