Skip to main content

Experimental congestive heart failure produced by rapid ventricular pacing in the dog: cardiac effects.

Publication ,  Journal Article
Wilson, JR; Douglas, P; Hickey, WF; Lanoce, V; Ferraro, N; Muhammad, A; Reichek, N
Published in: Circulation
April 1987

Chronic rapid ventricular pacing in the dog reportedly produces a useful preparation of low-output heart failure. However, little information is available regarding cardiac changes in this preparation. Accordingly, we evaluated the effects of both short-term (3 weeks) and prolonged (2 months) rapid ventricular pacing on cardiac hemodynamics, mass, and chamber size. The effects of short-term pacing on left ventricular wall thickening, blood flow, and metabolism were also examined. Compared with 16 control dogs, dogs paced for either 3 weeks (n = 8) or 2 months (n = 13) exhibited reduced cardiac outputs (control 130 +/- 20 ml/min/kg, 3 week pacing 112 +/- 19 ml/min/kg, 2 month pacing 116 +/- 14 ml/min/kg) and elevated pulmonary wedge pressures (control 10 +/- 3 mm Hg, 3 week pacing 26 +/- 5 mm Hg, 2 month pacing 26 +/- 8 mm Hg) and right atrial pressures (control 4 +/- 1 mm Hg, 3 week pacing 13 +/- 3 mm Hg, 2 month pacing 9 +/- 3 mm Hg) (all p less than .01 vs control). At the postmortem examination, both groups of paced dogs also exhibited increased left ventricular volumes (control 13 +/- 6 ml, 3 week pacing 27 +/- 6 ml, 2 month pacing 26 +/- 8 ml), right ventricular volumes (control 13 +/- 5 ml, 3 week pacing 27 +/- 9, 2 month pacing 24 +/- 7 ml), and right ventricular mass (control 27 +/- 5 g, 3 week pacing 32 +/- 6 g, 2 month pacing 34 +/- 6 g) (all p less than .03 vs control) but had normal left ventricular mass. Three weeks of pacing also decreased percent left ventricular shortening (34 +/- 6% to 17 +/- 7%) associated with a disproportionate deterioration of posterior wall thickening (58 +/- 16% to 17 +/- 18%) (both p less than .01), as assessed by echocardiography. This left ventricular dysfunction was associated with no change in myocardial lactate extraction (prepacing 40 +/- 10%, 3 week pacing 36 +/- 10%), myocardial arteriovenous O2 difference, or myocardial histology, suggesting that it was not due to myocardial ischemia. These data indicate that rapid ventricular pacing in the dog produces a useful experimental preparation of low-output heart failure characterized by biventricular pump dysfunction, biventricular cardiac dilation, and nonischemic impairment of left ventricular contractility.

Duke Scholars

Published In

Circulation

DOI

ISSN

0009-7322

Publication Date

April 1987

Volume

75

Issue

4

Start / End Page

857 / 867

Location

United States

Related Subject Headings

  • Time Factors
  • Organ Size
  • Myocardium
  • Male
  • Hemodynamics
  • Heart Ventricles
  • Heart Failure
  • Echocardiography
  • Dogs
  • Disease Models, Animal
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Wilson, J. R., Douglas, P., Hickey, W. F., Lanoce, V., Ferraro, N., Muhammad, A., & Reichek, N. (1987). Experimental congestive heart failure produced by rapid ventricular pacing in the dog: cardiac effects. Circulation, 75(4), 857–867. https://doi.org/10.1161/01.cir.75.4.857
Wilson, J. R., P. Douglas, W. F. Hickey, V. Lanoce, N. Ferraro, A. Muhammad, and N. Reichek. “Experimental congestive heart failure produced by rapid ventricular pacing in the dog: cardiac effects.Circulation 75, no. 4 (April 1987): 857–67. https://doi.org/10.1161/01.cir.75.4.857.
Wilson JR, Douglas P, Hickey WF, Lanoce V, Ferraro N, Muhammad A, et al. Experimental congestive heart failure produced by rapid ventricular pacing in the dog: cardiac effects. Circulation. 1987 Apr;75(4):857–67.
Wilson, J. R., et al. “Experimental congestive heart failure produced by rapid ventricular pacing in the dog: cardiac effects.Circulation, vol. 75, no. 4, Apr. 1987, pp. 857–67. Pubmed, doi:10.1161/01.cir.75.4.857.
Wilson JR, Douglas P, Hickey WF, Lanoce V, Ferraro N, Muhammad A, Reichek N. Experimental congestive heart failure produced by rapid ventricular pacing in the dog: cardiac effects. Circulation. 1987 Apr;75(4):857–867.

Published In

Circulation

DOI

ISSN

0009-7322

Publication Date

April 1987

Volume

75

Issue

4

Start / End Page

857 / 867

Location

United States

Related Subject Headings

  • Time Factors
  • Organ Size
  • Myocardium
  • Male
  • Hemodynamics
  • Heart Ventricles
  • Heart Failure
  • Echocardiography
  • Dogs
  • Disease Models, Animal