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Effect of closed-loop order processing on the time to initial antimicrobial therapy.

Publication ,  Journal Article
Panosh, N; Rew, R; Sharpe, M
Published in: Am J Health Syst Pharm
August 15, 2012

PURPOSE: The results of a study comparing the average time to initiation of i.v. antimicrobial therapy with closed-versus open-loop order entry and processing are reported. METHODS: A retrospective cohort study was performed to compare order-to-administration times for initial doses of i.v. antimicrobials before and after a closed-loop order-processing system including computerized prescriber order entry (CPOE) was implemented at a large medical center. A total of 741 i.v. antimicrobial administrations to adult patients during designated five-month preimplementation and postimplementation study periods were assessed. Drug-use reports generated by the pharmacy database were used to identify order-entry times, and medication administration records were reviewed to determine times of i.v. antimicrobial administration. RESULTS: The mean ± S.D. order-to-administration times before and after the implementation of the CPOE system and closed-loop order processing were 3.18 ± 2.60 and 2.00 ± 1.89 hours, respectively, a reduction of 1.18 hours (p < 0.0001). Closed-loop order processing was associated with significant reductions in the average time to initiation of i.v. therapy in all patient care areas evaluated (cardiology, general medicine, and oncology). The study results suggest that CPOE-based closed-loop order processing can play an important role in achieving compliance with current practice guidelines calling for increased efforts to ensure the prompt initiation of i.v. antimicrobials for severe infections (e.g., sepsis, meningitis). CONCLUSION: Implementation of a closed-loop order-processing system resulted in a significant decrease in order-to-administration times for i.v. antimicrobial therapy.

Duke Scholars

Published In

Am J Health Syst Pharm

DOI

EISSN

1535-2900

Publication Date

August 15, 2012

Volume

69

Issue

16

Start / End Page

1423 / 1426

Location

England

Related Subject Headings

  • Time Factors
  • Retrospective Studies
  • Pharmacy Service, Hospital
  • Pharmacology & Pharmacy
  • Medical Order Entry Systems
  • Humans
  • Baltimore
  • Anti-Infective Agents
  • Adult
  • Administration, Intravenous
 

Citation

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MLA
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Panosh, N., Rew, R., & Sharpe, M. (2012). Effect of closed-loop order processing on the time to initial antimicrobial therapy. Am J Health Syst Pharm, 69(16), 1423–1426. https://doi.org/10.2146/ajhp100644
Panosh, Nicole, Richardd Rew, and Michelle Sharpe. “Effect of closed-loop order processing on the time to initial antimicrobial therapy.Am J Health Syst Pharm 69, no. 16 (August 15, 2012): 1423–26. https://doi.org/10.2146/ajhp100644.
Panosh N, Rew R, Sharpe M. Effect of closed-loop order processing on the time to initial antimicrobial therapy. Am J Health Syst Pharm. 2012 Aug 15;69(16):1423–6.
Panosh, Nicole, et al. “Effect of closed-loop order processing on the time to initial antimicrobial therapy.Am J Health Syst Pharm, vol. 69, no. 16, Aug. 2012, pp. 1423–26. Pubmed, doi:10.2146/ajhp100644.
Panosh N, Rew R, Sharpe M. Effect of closed-loop order processing on the time to initial antimicrobial therapy. Am J Health Syst Pharm. 2012 Aug 15;69(16):1423–1426.
Journal cover image

Published In

Am J Health Syst Pharm

DOI

EISSN

1535-2900

Publication Date

August 15, 2012

Volume

69

Issue

16

Start / End Page

1423 / 1426

Location

England

Related Subject Headings

  • Time Factors
  • Retrospective Studies
  • Pharmacy Service, Hospital
  • Pharmacology & Pharmacy
  • Medical Order Entry Systems
  • Humans
  • Baltimore
  • Anti-Infective Agents
  • Adult
  • Administration, Intravenous