Potential role of aerosolized amphotericin B formulations in the prevention and adjunctive treatment of invasive fungal infections.

Published

Journal Article (Review)

The incidence of invasive fungal infections (IFIs) continues to increase, largely due to the steady rise in the number of at-risk patients and the increased use of aggressive immunosuppressant agents. Many available treatments are often limited by concerns about efficacy, safety, drug interactions, and/or cost. Owing to the poor treatment outcomes of immunosuppressed patients with IFIs, new preventative and treatment strategies are being investigated. Among these are the aerosolized formulations of amphotericin B. Published experience with the use of aerosolized amphotericin B deoxycholate (AmBd) in the prevention of IFIs has raised concerns regarding challenges in drug administration and tolerability. However, evolving data regarding administration of lipid-based formulations of amphotericin B indicate potential advantages over AmBd in the prevention and adjunctive treatment of IFIs.

Full Text

Duke Authors

Cited Authors

  • Drew, R

Published Date

  • June 2006

Published In

Volume / Issue

  • 27 Suppl 1 /

Start / End Page

  • 36 - 44

PubMed ID

  • 16713192

Pubmed Central ID

  • 16713192

International Standard Serial Number (ISSN)

  • 0924-8579

Digital Object Identifier (DOI)

  • 10.1016/j.ijantimicag.2006.03.018

Language

  • eng

Conference Location

  • Netherlands