Design of aerosolized amphotericin b formulations for prophylaxis trials among lung transplant recipients.

Published

Journal Article

BACKGROUND: Emphasis has been placed on the need for antifungal prophylaxis when transplanted organs are directly exposed to the environment. In lung transplantation, one strategy for prevention has been aerosolization of polyenes into the lung. Despite widespread use of amphotericin B aerosols, there are still few studies on how to validate their effectiveness or optimize pharmacokinetics. METHODS: We compared results of several of our own studies of lung transplant recipients receiving formulations of amphotericin B with results of other studies. RESULTS: Recent aerosol studies suggest that aerosols of a lipid formulation of amphotericin B are safe and better tolerated than is amphotericin B deoxycholate. Their use in prophylaxis is associated with very few pulmonary fungal infections. CONCLUSION: This safe drug delivery at a local body site to directly protect the transplanted organ without systemic antifungal drug exposure is attractive from a cost and toxicity standpoint. However, careful multicenter, comparative studies are still needed to ensure that this strategy is consistently successful.

Full Text

Duke Authors

Cited Authors

  • Perfect, JR; Dodds Ashley, E; Drew, R

Published Date

  • October 15, 2004

Published In

Volume / Issue

  • 39 Suppl 4 /

Start / End Page

  • S207 - S210

PubMed ID

  • 15546119

Pubmed Central ID

  • 15546119

Electronic International Standard Serial Number (EISSN)

  • 1537-6591

Digital Object Identifier (DOI)

  • 10.1086/421958

Language

  • eng

Conference Location

  • United States