Hepatitis B vaccines in patients with chronic renal failure before dialysis.
Journal Article (Clinical Trial;Journal Article)
Hepatitis B remains a significant risk to patients receiving chronic hemodialysis, but no certain method of prevention has been identified. We tested two vaccines, plasma-derived vaccine (40-micrograms dose) and recombinant-derived vaccine (40-micrograms and 20-micrograms doses), in 61 patients with chronic renal failure who were not yet dependent on dialysis. Patients were followed up clinically and with laboratory tests of kidney function and hepatitis B virus serology for one year. Significantly more recipients of plasma-derived vaccine responded to vaccination; they also achieved a higher titer of antibody to hepatitis B virus than did recipients of recombinant-derived vaccine when evaluated at 6, 7, 9, and 12 mo after vaccination. No serious side effects were observed with any vaccine preparation, nor were excessive adverse effects observed in any group. Compared with the dialysis patients previously studied, patients with renal failure who were not yet dependent on dialysis responded more favorably to the hepatitis B virus vaccine.
Full Text
Duke Authors
Cited Authors
- Seaworth, B; Drucker, J; Starling, J; Drucker, R; Stevens, C; Hamilton, J
Published Date
- February 1, 1988
Published In
Volume / Issue
- 157 / 2
Start / End Page
- 332 - 337
PubMed ID
- 2961818
Pubmed Central ID
- 2961818
International Standard Serial Number (ISSN)
- 0022-1899
Digital Object Identifier (DOI)
- 10.1093/infdis/157.2.332
Language
- eng
Conference Location
- United States