Incorporating heterogeneous intercourse records into time to pregnancy models

Journal Article (Journal Article)

Information on the timing of intercourse relative to ovulation can be incorporated into time to pregnancy models to improve the power to detect covariate effects, to estimate the day-specific conception probabilities, and to distinguish between biological and behavioral effects on fecundability, and therefore the probability of conception in a menstrual cycle. In this paper, Bayesian methods are proposed for joint modeling of intercourse behavior and biologic fecundability. The model accommodates a sterile subpopulation of couples, general covariate effects, and heterogeneity among fecund couples in menstrual cycle viability and in frequency of unprotected intercourse. Methods are described for incorporating cycles with varying amounts of intercourse information into a single analysis. A Markov chain Monte Carlo algorithm is outlined for estimation of the posterior distributions of the unknowns. The methods arc applied to data from a North Carolina study of couples attempting pregnancy. Copyright © 2003 Taylor Francis.

Full Text

Duke Authors

Cited Authors

  • Dunson, DB

Published Date

  • April 1, 2003

Published In

Volume / Issue

  • 10 / 2

Start / End Page

  • 127 - 143

Electronic International Standard Serial Number (EISSN)

  • 1547-724X

International Standard Serial Number (ISSN)

  • 0889-8480

Digital Object Identifier (DOI)

  • 10.1080/08898480306714

Citation Source

  • Scopus