Bayesian models for multivariate current status data with informative censoring.

Published

Journal Article

Multivariate current status data, consist of indicators of whether each of several events occur by the time of a single examination. Our interest focuses on inferences about the joint distribution of the event times. Conventional methods for analysis of multiple event-time data cannot be used because all of the event times are censored and censoring may be informative. Within a given subject, we account for correlated event times through a subject-specific latent variable, conditional upon which the various events are assumed to occur independently. We also assume that each event contributes independently to the hazard of censoring. Nonparametric step functions are used to characterize the baseline distributions of the different event times and of the examination times. Covariate and subject-specific effects are incorporated through generalized linear models. A Markov chain Monte Carlo algorithm is described for estimation of the posterior distributions of the unknowns. The methods are illustrated through application to multiple tumor site data from an animal carcinogenicity study.

Full Text

Duke Authors

Cited Authors

  • Dunson, DB; Dinse, GE

Published Date

  • March 2002

Published In

Volume / Issue

  • 58 / 1

Start / End Page

  • 79 - 88

PubMed ID

  • 11890330

Pubmed Central ID

  • 11890330

Electronic International Standard Serial Number (EISSN)

  • 1541-0420

International Standard Serial Number (ISSN)

  • 0006-341X

Digital Object Identifier (DOI)

  • 10.1111/j.0006-341x.2002.00079.x

Language

  • eng