Design automation for DNA self-assembled nanostructures

Journal Article

DNA self-assembly is an emerging technology with potential as a future replacement of conventional lithographic fabrication. A key challenge is the specification of appropriate DNA sequences that are optimal according to specified metrics and satisfy various design rules. To meet this challenge we developed a thermodynamics-based design automation tool to evaluate the vast DNA sequence space (2.8k base pairs) and select appropriate sequences. We use this tool to design DNA nanostructures that were previously impossible with existing text distance based tools. We also show that for nanoscale structures our approach produces superior results compared to existing tools. Copyright 2006 ACM.

Full Text

Duke Authors

Cited Authors

  • Pistol, C; Lebeck, AR; Dwyer, C

Published Date

  • December 1, 2006

Published In

Start / End Page

  • 919 - 924

International Standard Serial Number (ISSN)

  • 0738-100X

Digital Object Identifier (DOI)

  • 10.1145/1146909.1147143

Citation Source

  • Scopus