Molecular mechanism of juxtaglomerular cell hyperplasia: a unifying hypothesis.

Journal Article

Renin is the first enzymatic step of the renin angiotensin cascade and plays an important role in cardiovascular homeostasis. Renin is mainly expressed in and released from specialized juxtaglomerular (JG) cells in kidney. JG cells develop hyperplasia in response to various chronic stimuli while maintaining the ability to express high levels of renin. However, the molecular and cellular mechanisms of JG cell hyperplasia are unknown. Based on the authors' previous observation that a nuclear hormone receptor, liver X receptor alpha, regulates renin expression as well as growth and differentiation genes such as c-myc, the authors propose the hypothesis that liver X receptor alpha can contribute to JG cell hyperplasia under conditions of chronic and intense induction of these genes. This hypothesis may provide a potential explanation for the observation that the JG cells can maintain a highly specialized renin-producing phenotype while undergoing hyperplasia.

Full Text

Duke Authors

Cited Authors

  • Matsushita, K; Zhang, Z; Pratt, RE; Dzau, VJ

Published Date

  • May 2007

Published In

Volume / Issue

  • 1 / 3

Start / End Page

  • 164 - 168

PubMed ID

  • 20409848

International Standard Serial Number (ISSN)

  • 1933-1711

Digital Object Identifier (DOI)

  • 10.1016/j.jash.2007.02.004

Language

  • eng

Conference Location

  • United States