Skip to main content

Endothelium-targeted gene and cell-based therapies for cardiovascular disease.

Publication ,  Journal Article
Melo, LG; Gnecchi, M; Pachori, AS; Kong, D; Wang, K; Liu, X; Pratt, RE; Dzau, VJ
Published in: Arterioscler Thromb Vasc Biol
October 2004

Most common cardiovascular diseases are accompanied by endothelial dysfunction. Because of its predominant role in the pathogenesis of cardiovascular disease, the vascular endothelium is an attractive therapeutic target. The identification of promoter sequences capable of rendering endothelial-specific transgene expression together with the recent development of vectors with enhanced tropism for endothelium may offer opportunities for the design of new strategies for modulation of endothelial function. Such strategies may be useful in the treatment of chronic diseases such as hypertension, atherosclerosis, and ischemic artery disease, as well as in acute myocardial infarction and during open heart surgery for prevention of ischemia and reperfusion (I/R)-induced injury. The recent identification of putative endothelial progenitor cells in peripheral blood may allow the design of autologous cell-based strategies for neovascularization of ischemic tissues and for the repair of injured blood vessels and bioengineering of vascular prosthesis. "Proof-of-concept" for some of these strategies has been established in animal models of cardiovascular disease. However the successful translation of these novel strategies into clinical application will require further developments in vector and delivery technologies. Further characterization of the processes involved in mobilization, migration, homing, and incorporation of endothelial progenitor cells into the target tissues is necessary, and the optimal conditions for therapeutic application of these cells need to be defined and standardized.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Arterioscler Thromb Vasc Biol

DOI

EISSN

1524-4636

Publication Date

October 2004

Volume

24

Issue

10

Start / End Page

1761 / 1774

Location

United States

Related Subject Headings

  • Humans
  • Genetic Therapy
  • Gene Transfer Techniques
  • Endothelium, Vascular
  • Endothelial Cells
  • Cardiovascular System & Hematology
  • Cardiovascular Diseases
  • Animals
  • 3202 Clinical sciences
  • 3201 Cardiovascular medicine and haematology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Melo, L. G., Gnecchi, M., Pachori, A. S., Kong, D., Wang, K., Liu, X., … Dzau, V. J. (2004). Endothelium-targeted gene and cell-based therapies for cardiovascular disease. Arterioscler Thromb Vasc Biol, 24(10), 1761–1774. https://doi.org/10.1161/01.ATV.0000142363.15113.88
Melo, Luis G., Massimiliano Gnecchi, Alok S. Pachori, Deling Kong, Kai Wang, Xiaoli Liu, Richard E. Pratt, and Victor J. Dzau. “Endothelium-targeted gene and cell-based therapies for cardiovascular disease.Arterioscler Thromb Vasc Biol 24, no. 10 (October 2004): 1761–74. https://doi.org/10.1161/01.ATV.0000142363.15113.88.
Melo LG, Gnecchi M, Pachori AS, Kong D, Wang K, Liu X, et al. Endothelium-targeted gene and cell-based therapies for cardiovascular disease. Arterioscler Thromb Vasc Biol. 2004 Oct;24(10):1761–74.
Melo, Luis G., et al. “Endothelium-targeted gene and cell-based therapies for cardiovascular disease.Arterioscler Thromb Vasc Biol, vol. 24, no. 10, Oct. 2004, pp. 1761–74. Pubmed, doi:10.1161/01.ATV.0000142363.15113.88.
Melo LG, Gnecchi M, Pachori AS, Kong D, Wang K, Liu X, Pratt RE, Dzau VJ. Endothelium-targeted gene and cell-based therapies for cardiovascular disease. Arterioscler Thromb Vasc Biol. 2004 Oct;24(10):1761–1774.

Published In

Arterioscler Thromb Vasc Biol

DOI

EISSN

1524-4636

Publication Date

October 2004

Volume

24

Issue

10

Start / End Page

1761 / 1774

Location

United States

Related Subject Headings

  • Humans
  • Genetic Therapy
  • Gene Transfer Techniques
  • Endothelium, Vascular
  • Endothelial Cells
  • Cardiovascular System & Hematology
  • Cardiovascular Diseases
  • Animals
  • 3202 Clinical sciences
  • 3201 Cardiovascular medicine and haematology