Physiological genomics of human arteries: quantitative relationship between gene expression and arterial stiffness.

Journal Article

BACKGROUND: Previous genomic studies with human tissues have compared differential gene expression between 2 conditions (ie, normal versus diseased) to identify altered gene expression in a binary manner; however, a potentially more informative approach is to correlate the levels of gene expression with quantitative physiological parameters. METHODS AND RESULTS: In this study, we have used this approach to examine genes whose expression correlates with arterial stiffness in human aortic specimens. Our data identify 2 distinct groups of genes, those associated with cell signaling and those associated with the mechanical regulation of vascular structure (cytoskeletal-cell membrane-extracellular matrix). Although previous studies have concentrated on the contribution of the latter group toward arterial stiffness, our data suggest that changes in expression of signaling molecules play an equally important role. Alterations in the profiles of signaling molecules could be involved in the regulation of cell cytoskeletal organization, cell-matrix interactions, or the contractile state of the cell. CONCLUSIONS: Although the influence of smooth muscle contraction/relaxation on arterial stiffness could be controversial, our provocative data would suggest that further studies on this subject are indicated.

Full Text

Duke Authors

Cited Authors

  • Durier, S; Fassot, C; Laurent, S; Boutouyrie, P; Couetil, J-P; Fine, E; Lacolley, P; Dzau, VJ; Pratt, RE

Published Date

  • October 14, 2003

Published In

Volume / Issue

  • 108 / 15

Start / End Page

  • 1845 - 1851

PubMed ID

  • 14530203

Electronic International Standard Serial Number (EISSN)

  • 1524-4539

Digital Object Identifier (DOI)

  • 10.1161/01.CIR.0000091407.86925.7A

Language

  • eng

Conference Location

  • United States