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Chromosomal distribution of the human cardiovascular transcriptome.

Publication ,  Journal Article
Barrans, JD; Ip, J; Lam, C-W; Hwang, IL; Dzau, VJ; Liew, C-C
Published in: Genomics
May 2003

On the basis of previous observations in chromosomes 21 and 22, we hypothesize that there is a tissue-specific organization of cardiovascular gene transcripts in the human genome. To examine the distribution of heart-derived transcripts, we assigned a nonredundant set of 4628 fetal and 3574 adult known and uncharacterized cardiovascular expressed-sequence tags (cvESTs) to 5-Mb chromosomal 'windows' on the basis of publicly available sequence mapping data. On a whole-genome level (36,617 genes), chromosome 17 (19.2% in fetal, 16.5% in adult) contained the highest proportion of cvESTs, whereas chromosome Y (2.0% in fetal and adult) contained the lowest. In total, 50 of the 639 windows contained a significantly higher proportion of cvESTs (P < 0.003) compared with the genome-wide cvEST gene density, particularly on gene-dense chromosomes (that is, 17, 19, 22) as opposed to gene-rich chromosomes (for example, 1, 2, 11). This report provides insight into a possible role for complex tissue-specific gene regulation in the human genome.

Duke Scholars

Published In

Genomics

DOI

ISSN

0888-7543

Publication Date

May 2003

Volume

81

Issue

5

Start / End Page

519 / 524

Location

United States

Related Subject Headings

  • Humans
  • Genetics & Heredity
  • Gene Expression Profiling
  • Expressed Sequence Tags
  • Databases, Nucleic Acid
  • DNA, Complementary
  • Chromosome Mapping
  • Cardiovascular System
  • 3105 Genetics
  • 0806 Information Systems
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Barrans, J. D., Ip, J., Lam, C.-W., Hwang, I. L., Dzau, V. J., & Liew, C.-C. (2003). Chromosomal distribution of the human cardiovascular transcriptome. Genomics, 81(5), 519–524. https://doi.org/10.1016/s0888-7543(03)00008-9
Barrans, J David, James Ip, Ching-Wan Lam, Irene L. Hwang, Victor J. Dzau, and Choong-Chin Liew. “Chromosomal distribution of the human cardiovascular transcriptome.Genomics 81, no. 5 (May 2003): 519–24. https://doi.org/10.1016/s0888-7543(03)00008-9.
Barrans JD, Ip J, Lam C-W, Hwang IL, Dzau VJ, Liew C-C. Chromosomal distribution of the human cardiovascular transcriptome. Genomics. 2003 May;81(5):519–24.
Barrans, J. David, et al. “Chromosomal distribution of the human cardiovascular transcriptome.Genomics, vol. 81, no. 5, May 2003, pp. 519–24. Pubmed, doi:10.1016/s0888-7543(03)00008-9.
Barrans JD, Ip J, Lam C-W, Hwang IL, Dzau VJ, Liew C-C. Chromosomal distribution of the human cardiovascular transcriptome. Genomics. 2003 May;81(5):519–524.
Journal cover image

Published In

Genomics

DOI

ISSN

0888-7543

Publication Date

May 2003

Volume

81

Issue

5

Start / End Page

519 / 524

Location

United States

Related Subject Headings

  • Humans
  • Genetics & Heredity
  • Gene Expression Profiling
  • Expressed Sequence Tags
  • Databases, Nucleic Acid
  • DNA, Complementary
  • Chromosome Mapping
  • Cardiovascular System
  • 3105 Genetics
  • 0806 Information Systems