A genome scan for hypertension susceptibility loci in populations of Chinese and Japanese origins

Journal Article

Background: Our understanding of genes that predispose to essential hypertension is poor. Methods: A genome-wide scan for linkage at ∼10 cM resolution was done on 1425 sibpairs of Chinese and Japanese origins that were concordant for hypertension (N = 661), low-normal blood pressure (BP) (N = 184), or discordant for BP (N = 580). Results: There was no significant evidence of linkage to a single locus in the genome. There was suggestive evidence of linkage to chromosome 10p, with a LOD score of 2.5. Conclusions: We can exclude the possibility that a single gene accounts for at least 15% of the variance in hypertension in this population. © 2003 American Journal of Hypertension, Ltd.

Full Text

Duke Authors

Cited Authors

  • Ranade, K; Hinds, D; Hsiung, CA; Chuang, L-M; Chang, M-S; Chen, Y-T; Pesich, R; Hebert, J; Chen, Y-DI; Dzau, V; Olshen, R; Curb, D; Botstein, D; Cox, DR; Risch, N

Published Date

  • 2003

Published In

  • American Journal of Hypertension

Volume / Issue

  • 16 / 2

Start / End Page

  • 158 - 162

PubMed ID

  • 12559686

Digital Object Identifier (DOI)

  • 10.1016/S0895-7061(02)03245-4