Molecular approaches for the treatment of atherosclerosis.

Journal Article (Journal Article;Review)

Advances in vascular biology and the study of molecular pathophysiology have enabled the design and initial testing of therapeutic principles for cardiovascular intervention at the level of gene expression. This approach can offer an avenue to greatly impact the onset and progression of vascular disease at its roots. Early translations of basic research into human clinical protocols might provide novel alternatives for patients without traditional therapeutic options and might provide means of improving and prolonging the success of standard therapies. As the understanding of the genetic basis of vascular disease continues to grow and the tools for in vivo genetic manipulation continue to improve, vascular gene therapies might someday become a part of routine patient care.

Full Text

Duke Authors

Cited Authors

  • Mann, MJ; Dzau, VJ

Published Date

  • November 2002

Published In

Volume / Issue

  • 20 / 4

Start / End Page

  • 633 - 643

PubMed ID

  • 12472049

International Standard Serial Number (ISSN)

  • 0733-8651

Digital Object Identifier (DOI)

  • 10.1016/s0733-8651(02)00069-3


  • eng

Conference Location

  • Netherlands