Skip to main content
Journal cover image

The relevance of tissue angiotensin-converting enzyme: manifestations in mechanistic and endpoint data.

Publication ,  Journal Article
Dzau, VJ; Bernstein, K; Celermajer, D; Cohen, J; Dahlöf, B; Deanfield, J; Diez, J; Drexler, H; Ferrari, R; van Gilst, W; Hansson, L; Hornig, B ...
Published in: Am J Cardiol
November 8, 2001

Angiotensin-converting enzyme (ACE) is primarily localized (>90%) in various tissues and organs, most notably on the endothelium but also within parenchyma and inflammatory cells. Tissue ACE is now recognized as a key factor in cardiovascular and renal diseases. Endothelial dysfunction, in response to a number of risk factors or injury such as hypertension, diabetes mellitus, hypercholesteremia, and cigarette smoking, disrupts the balance of vasodilation and vasoconstriction, vascular smooth muscle cell growth, the inflammatory and oxidative state of the vessel wall, and is associated with activation of tissue ACE. Pathologic activation of local ACE can have deleterious effects on the heart, vasculature, and the kidneys. The imbalance resulting from increased local formation of angiotensin II and increased bradykinin degradation favors cardiovascular disease. Indeed, ACE inhibitors effectively reduce high blood pressure and exert cardio- and renoprotective actions. Recent evidence suggests that a principal target of ACE inhibitor action is at the tissue sites. Pharmacokinetic properties of various ACE inhibitors indicate that there are differences in their binding characteristics for tissue ACE. Clinical studies comparing the effects of antihypertensives (especially ACE inhibitors) on endothelial function suggest differences. More comparative experimental and clinical studies should address the significance of these drug differences and their impact on clinical events.

Duke Scholars

Published In

Am J Cardiol

DOI

ISSN

0002-9149

Publication Date

November 8, 2001

Volume

88

Issue

9A

Start / End Page

1L / 20L

Location

United States

Related Subject Headings

  • Ventricular Dysfunction, Left
  • Peptidyl-Dipeptidase A
  • Myocardium
  • Kidney Diseases
  • Kidney
  • Humans
  • Heart
  • Endothelium, Vascular
  • Coronary Disease
  • Cardiovascular System & Hematology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Dzau, V. J., Bernstein, K., Celermajer, D., Cohen, J., Dahlöf, B., Deanfield, J., … Working Group on Tissue Angiotensin-converting enzyme, International Society of Cardiovascular Pharmacotherapy, . (2001). The relevance of tissue angiotensin-converting enzyme: manifestations in mechanistic and endpoint data. Am J Cardiol, 88(9A), 1L-20L. https://doi.org/10.1016/s0002-9149(01)01878-1
Dzau, V. J., K. Bernstein, D. Celermajer, J. Cohen, B. Dahlöf, J. Deanfield, J. Diez, et al. “The relevance of tissue angiotensin-converting enzyme: manifestations in mechanistic and endpoint data.Am J Cardiol 88, no. 9A (November 8, 2001): 1L-20L. https://doi.org/10.1016/s0002-9149(01)01878-1.
Dzau VJ, Bernstein K, Celermajer D, Cohen J, Dahlöf B, Deanfield J, et al. The relevance of tissue angiotensin-converting enzyme: manifestations in mechanistic and endpoint data. Am J Cardiol. 2001 Nov 8;88(9A):1L-20L.
Dzau, V. J., et al. “The relevance of tissue angiotensin-converting enzyme: manifestations in mechanistic and endpoint data.Am J Cardiol, vol. 88, no. 9A, Nov. 2001, pp. 1L-20L. Pubmed, doi:10.1016/s0002-9149(01)01878-1.
Dzau VJ, Bernstein K, Celermajer D, Cohen J, Dahlöf B, Deanfield J, Diez J, Drexler H, Ferrari R, van Gilst W, Hansson L, Hornig B, Husain A, Johnston C, Lazar H, Lonn E, Lüscher T, Mancini J, Mimran A, Pepine C, Rabelink T, Remme W, Ruilope L, Ruzicka M, Schunkert H, Swedberg K, Unger T, Vaughan D, Weber M, Working Group on Tissue Angiotensin-converting enzyme, International Society of Cardiovascular Pharmacotherapy. The relevance of tissue angiotensin-converting enzyme: manifestations in mechanistic and endpoint data. Am J Cardiol. 2001 Nov 8;88(9A):1L-20L.
Journal cover image

Published In

Am J Cardiol

DOI

ISSN

0002-9149

Publication Date

November 8, 2001

Volume

88

Issue

9A

Start / End Page

1L / 20L

Location

United States

Related Subject Headings

  • Ventricular Dysfunction, Left
  • Peptidyl-Dipeptidase A
  • Myocardium
  • Kidney Diseases
  • Kidney
  • Humans
  • Heart
  • Endothelium, Vascular
  • Coronary Disease
  • Cardiovascular System & Hematology