Genetic variation in aldosterone synthase predicts plasma glucose levels.


Journal Article

The mineralocorticoid hormone, aldosterone, is known to play a role in sodium homeostasis. We serendipitously found, however, highly significant association between single-nucleotide polymorphisms in the aldosterone synthase gene and plasma glucose levels in a large population of Chinese and Japanese origin. Two polymorphisms--one in the putative promoter (T-344C) and another resulting in a lysine/arginine substitution at amino acid 173, which are in complete linkage disequilibrium in this population--were associated with fasting plasma glucose levels (P = 0.000017) and those 60 (P = 0.017) and 120 (P = 0.0019) min after an oral glucose challenge. A C/T variant in intron 1, between these polymorphisms, was not associated with glucose levels. Arg-173 and -344C homozygotes were most likely to be diabetic [odds ratio 2.51; 95% confidence interval (C.I.) 1.39-3.92; P = 0.0015] and have impaired fasting glucose levels (odds ratio 3.53; 95% C.I. 2.02-5.5; P = 0.0000036). These results suggest a new role for aldosterone in glucose homeostasis.

Full Text

Duke Authors

Cited Authors

  • Ranade, K; Wu, KD; Risch, N; Olivier, M; Pei, D; Hsiao, CF; Chuang, LM; Ho, LT; Jorgenson, E; Pesich, R; Chen, YD; Dzau, V; Lin, A; Olshen, RA; Curb, D; Cox, DR; Botstein, D

Published Date

  • November 6, 2001

Published In

Volume / Issue

  • 98 / 23

Start / End Page

  • 13219 - 13224

PubMed ID

  • 11687612

Pubmed Central ID

  • 11687612

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.221467098


  • eng

Conference Location

  • United States