The angiotensin II type 2 (AT2) receptor antagonizes the growth effects of the AT1 receptor: gain-of-function study using gene transfer.

Published

Journal Article

The type 1 angiotensin II (AT1) receptor is well characterized but the type 2 (AT2) receptor remains an enigma. We tested the hypothesis that the AT2 receptor can modulate the growth of vascular smooth muscle cells by transfecting an AT2 receptor expression vector into the balloon-injured rat carotid artery and observed that overexpression of the AT2 receptor attenuated neointimal formation. In cultured smooth muscle cells, AT2 receptor transfection reduced proliferation and inhibited mitogen-activated protein kinase activity. Furthermore, we demonstrated that the AT2 receptor mediated the developmentally regulated decrease in aortic DNA synthesis at the latter stages of gestation. These results suggest that the AT2 receptor exerts an antiproliferative effect, counteracting the growth action of AT1 receptor.

Full Text

Duke Authors

Cited Authors

  • Nakajima, M; Hutchinson, HG; Fujinaga, M; Hayashida, W; Morishita, R; Zhang, L; Horiuchi, M; Pratt, RE; Dzau, VJ

Published Date

  • November 7, 1995

Published In

Volume / Issue

  • 92 / 23

Start / End Page

  • 10663 - 10667

PubMed ID

  • 7479861

Pubmed Central ID

  • 7479861

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.92.23.10663

Language

  • eng

Conference Location

  • United States