Differential effects of antihypertensive agents in experimental and human atherosclerosis.

Journal Article (Journal Article;Review)

The association between hypertension and atherosclerosis is complex, incorporating endothelial dysfunction, abnormalities of insulin and lipid metabolism, altered vascular biology, and impaired arterial compliance. Results of experimental and human studies suggest that there is heterogeneity in the manifestations of disease and responses to therapy among different animal species, vascular territories, and individual patients. Antihypertensive therapy requires the careful selection of specific agents that reduce blood pressure and preferentially and positively modulate the synergistic interaction of the many facets of disease, with the goal of preventing or regressing atherosclerosis. Angiotensin-converting enzyme (ACE) inhibitors, calcium antagonists, and alpha-blockers appear to hold the greatest promise in this regard.

Full Text

Duke Authors

Cited Authors

  • Omoigui, N; Dzau, VJ

Published Date

  • March 1, 1993

Published In

Volume / Issue

  • 6 / 3 Pt 2

Start / End Page

  • 30S - 39S

PubMed ID

  • 8466724

International Standard Serial Number (ISSN)

  • 0895-7061

Digital Object Identifier (DOI)

  • 10.1093/ajh/6.3.30s


  • eng

Conference Location

  • United States