Tissue renin-angiotensin system in myocardial hypertrophy and failure.

Published

Journal Article (Review)

The renin-angiotensin system traditionally has been conceived as a neuroendocrine system functioning in the circulation. Recent research has confirmed the existence of autocrine/paracrine tissue renin-angiotensin systems present and functioning at multiple sites, including cardiac, vascular, and renal tissues, which contain the majority of angiotensin-converting enzyme in the body. It appears that the circulating renin-angiotensin system is activated acutely to maintain homeostasis and is then turned off at cardiovascular compensation, while the tissue renin-angiotensin systems exert long-term actions that affect cardiovascular function and structure, which may play a pathophysiological role in congestive heart failure, hypertension, and vascular disease and influence the response to therapy with angiotensin-converting enzyme-inhibiting agents.

Full Text

Duke Authors

Cited Authors

  • Dzau, VJ

Published Date

  • April 26, 1993

Published In

Volume / Issue

  • 153 / 8

Start / End Page

  • 937 - 942

PubMed ID

  • 8386920

Pubmed Central ID

  • 8386920

International Standard Serial Number (ISSN)

  • 0003-9926

Language

  • eng

Conference Location

  • United States