Local contractile and growth modulators in the myocardium.

Journal Article (Journal Article;Review)

Symptomatic congestive heart failure is the culmination of a process that evolves over many years. The long preclinical, or "incubation," period is the setting for a broad range of so-called local activities, including those involved in myocardial remodeling. Growth factors, cytokines, and vasoactive substances are central to this dynamic process, as are different populations of myocardial and circulating cells. The effects of angiotensin, endothelin, endothelium-derived relaxing factor, transforming growth factor-beta, and platelet-derived growth factor on myocardial structure, contractile function, and blood flow are outlined. The mechanisms involved in the activation of interleukin-1 and of tumor necrosis factor are examined within the context of the pathologic process.

Full Text

Duke Authors

Cited Authors

  • Dzau, VJ

Published Date

  • May 1993

Published In

Volume / Issue

  • 16 / 5 Suppl 2

Start / End Page

  • II5 - II9

PubMed ID

  • 8504588

International Standard Serial Number (ISSN)

  • 0160-9289

Digital Object Identifier (DOI)

  • 10.1002/clc.4960161403


  • eng

Conference Location

  • United States