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Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans.

Publication ,  Journal Article
Creager, MA; Cooke, JP; Mendelsohn, ME; Gallagher, SJ; Coleman, SM; Loscalzo, J; Dzau, VJ
Published in: J Clin Invest
July 1990

The effect of hypercholesterolemia on vascular function was studied in humans. To eliminate the potential confounding effects of atherosclerosis, vascular reactivity was measured in the forearm resistance vessels of 11 normal subjects (serum LDL cholesterol = 111 +/- 7 mg/dl) and 13 patients with hypercholesterolemia (serum LDL cholesterol = 211 +/- 19 mg/dl, P less than 0.05). Each subject received intrabrachial artery infusions of methacholine, which releases endothelium-derived relaxant factor, and nitroprusside which directly stimulates guanylate cyclase in vascular smooth muscle. Maximal vasodilatory potential was determined during reactive hyperemia. Vasoconstrictive responsiveness was examined during intra-arterial phenylephrine infusion. Forearm blood flow was determined by venous occlusion plethysmography. Basal forearm blood flow in normal and hypercholesterolemic subjects was comparable. Similarly, reactive hyperemic blood flow did not differ between the two groups. In contrast, the maximal forearm blood flow response to methacholine in hypercholesterolemic subjects was less than that observed in normal subjects. In addition, the forearm blood flow response to nitroprusside was less in hypercholesterolemic subjects. There was no difference in the forearm vasoconstrictive response to phenylephrine in the two groups. Thus, the vasodilator responses to methacholine and nitroprusside were blunted in patients with hypercholesterolemia. We conclude that in humans with hypercholesterolemia, there is a decreased effect of nitrovasodilators, including endothelium-derived relaxing factor, on the vascular smooth muscle of resistance vessels.

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Published In

J Clin Invest

DOI

ISSN

0021-9738

Publication Date

July 1990

Volume

86

Issue

1

Start / End Page

228 / 234

Location

United States

Related Subject Headings

  • Vasodilation
  • Regional Blood Flow
  • Phenylephrine
  • Nitroprusside
  • Methacholine Compounds
  • Methacholine Chloride
  • Male
  • Immunology
  • Hypercholesterolemia
  • Humans
 

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Creager, M. A., Cooke, J. P., Mendelsohn, M. E., Gallagher, S. J., Coleman, S. M., Loscalzo, J., & Dzau, V. J. (1990). Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans. J Clin Invest, 86(1), 228–234. https://doi.org/10.1172/JCI114688
Creager, M. A., J. P. Cooke, M. E. Mendelsohn, S. J. Gallagher, S. M. Coleman, J. Loscalzo, and V. J. Dzau. “Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans.J Clin Invest 86, no. 1 (July 1990): 228–34. https://doi.org/10.1172/JCI114688.
Creager MA, Cooke JP, Mendelsohn ME, Gallagher SJ, Coleman SM, Loscalzo J, et al. Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans. J Clin Invest. 1990 Jul;86(1):228–34.
Creager, M. A., et al. “Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans.J Clin Invest, vol. 86, no. 1, July 1990, pp. 228–34. Pubmed, doi:10.1172/JCI114688.
Creager MA, Cooke JP, Mendelsohn ME, Gallagher SJ, Coleman SM, Loscalzo J, Dzau VJ. Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans. J Clin Invest. 1990 Jul;86(1):228–234.

Published In

J Clin Invest

DOI

ISSN

0021-9738

Publication Date

July 1990

Volume

86

Issue

1

Start / End Page

228 / 234

Location

United States

Related Subject Headings

  • Vasodilation
  • Regional Blood Flow
  • Phenylephrine
  • Nitroprusside
  • Methacholine Compounds
  • Methacholine Chloride
  • Male
  • Immunology
  • Hypercholesterolemia
  • Humans